Live and Let Dye: Visualizing the Cellular Compart... - BV FAPESP
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Live and Let Dye: Visualizing the Cellular Compartments of the Malaria Parasite Plasmodium falciparum

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Author(s):
Linzke, Marleen ; Yan, Sun Liu Rei ; Tarnok, Attila ; Ulrich, Henning ; Groves, Matthew R. ; Wrenger, Carsten
Total Authors: 6
Document type: Journal article
Source: Cytometry Part A; v. 97, n. 7, p. 12-pg., 2019-11-18.
Abstract

Malaria remains one of the deadliest diseases worldwide and it is caused by the protozoan parasite Plasmodium spp. Parasite visualization is an important tool for the correct detection of malarial cases but also to understand its biology. Advances in visualization techniques promote new insights into the complex life cycle and biology of Plasmodium parasites. Live cell imaging by fluorescence microscopy or flow cytometry are the foundation of the visualization technique for malaria research. In this review, we present an overview of possibilities in live cell imaging of the malaria parasite. We discuss some of the state-of-the-art techniques to visualize organelles and processes of the parasite and discuss limitation and advantages of each technique. (c) 2019 International Society for Advancement of Cytometry (AU)

FAPESP's process: 17/03966-4 - Targeting lipoic acid salvage and biosynthesis pathways in MRSA
Grantee:Carsten Wrenger
Support Opportunities: Regular Research Grants
FAPESP's process: 12/50880-4 - Stem cells: from basic studies of kinin and purinergic receptor roles towards therapeutical applications
Grantee:Alexander Henning Ulrich
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 14/23330-9 - Morphologic Analysis of the Apicoplast Formation in Plasmodium falciparum
Grantee:Marleen Linzke
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 12/50393-6 - Aptamers for diagnostic marker and therapeutic inhibitor discovery in infectious diseases
Grantee:Alexander Henning Ulrich
Support Opportunities: Regular Research Grants
FAPESP's process: 17/26358-0 - Dissection of the lipoic acid metabolism as druggable target in Malaria
Grantee:Sun Liu Rei Yan
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 15/26722-8 - Drug discovery against human infectious diseases
Grantee:Carsten Wrenger
Support Opportunities: Research Projects - Thematic Grants