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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Studies of the Electrochemical Degradation of Acetaminophen Using a Real-Time Biomimetic Sensor

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Author(s):
Quintino de Oliveira, Mariana Calora [1] ; Tanaka, Auro Atsushi [2] ; Roberto de Vasconce los Lanza, Marcos [3] ; Taboada Sotomayor, Maria Del Pilar [1]
Total Authors: 4
Affiliation:
[1] State Univ Sao Paulo UNESP, Dept Analyt Chem, Inst Chem, BR-14801970 Araraquara, SP - Brazil
[2] Fed Univ Maranhao UFMA, Ctr Phys Sci & Technol, BR-65085580 Sao Luis, MA - Brazil
[3] Univ Sao Paulo, Dept Mol Phys Chem IQSC, BR-13560970 Sao Carlos, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: Electroanalysis; v. 23, n. 11, p. 2616-2621, NOV 2011.
Web of Science Citations: 2
Abstract

Real-time monitoring of the electrochemical degradation of acetaminophen was performed using a biomimetic sensor coupled to a flow injection analysis (FIA) system. Degradation of the drug was carried out at constant current density (24 to 180 mAcm(-2)) in an electrolyte consisting of 0.1 molL(-1) K(2)SO(4)/5.0 x 10(-4) molL(-1) FeSO(4)center dot 7H(2)O. Two commercial DSA anodes (DSA-Cl(2) and DSA-O(2)) were compared. The degradation process was monitored online using an amperometric sensor based on the biomimetic catalyst iron(III) tetrapyridinoporphyrazine (FeTPyPz), coupled to the degradation cell. The optimized FIA detection system employed the electrolyte solution as carrier, a flow rate of 1.25 mLmin(-1) and an injected sample volume of 75 mu L. The real-time data obtained showed, as expected, that acetaminophen degradation followed pseudo-first order kinetics, with the DSA-Cl(2) anode showing a higher efficiency according to the calculated apparent rate constant values. The advantage of the proposed on-line system is that a larger number of points can be monitored in a shorter time compared to other off-line methods, which improves the accuracy of estimates of electrochemical degradation constants. (AU)

FAPESP's process: 08/00303-5 - Construction of biomimetic sensors for drugs determination and their coupling in flow systems
Grantee:Maria Del Pilar Taboada Sotomayor
Support type: Regular Research Grants
FAPESP's process: 07/08314-3 - Organophosphrous pesticides degradation (chlorpyrifos, methyl-parathion and profenofos) via electrochemical and advanced oxidation processes
Grantee:Marcos Roberto de Vasconcelos Lanza
Support type: Regular Research Grants
FAPESP's process: 08/05899-3 - Coupling of a sensor and an electrochemical reactor for on line monitoring of the electrochemical degradation of
Grantee:Mariana Calora Quintino de Oliveira
Support type: Scholarships in Brazil - Scientific Initiation