Contribution of public oral pathology services to the diagnosis of oral and oropharyngeal cancer in Brazil

Author(s):Show less -

Brendo Vinicius Rodrigues LOUREDO ^[1] ; Maria Paula CURADO ^[2] ; Paulo Victor Mendes PENAFORT ^[3] ; José Alcides Almeida DE ARRUDA ^[4] ; Lucas Guimarães ABREU ^[5] ; Ricardo Alves MESQUITA ^[6] ; Décio dos Santos PINTO-JÚNIOR ^[7] ; Aline Corrêa ABRAHÃO ^[8] ; Bruno Augusto Benevenuto de ANDRADE ^[9] ; Michelle AGOSTINI ^[10] ; Renata Mendonça MORAES ^[11] ; Ana Lia ANBINDER ^[12] ; Pedro Henrique Silva DOURADO ^[13] ; Teresa Cristina Ribeiro Bartholomeu dos SANTOS ^[14] ; Fábio Ramoa PIRES ^[15] ; Natalia Cristina Trentin BORDIGNON ^[16] ; Rogério Oliveira GONDAK ^[17] ; Marcia Gaiger DE OLIVEIRA ^[18] ; Vinicius Coelho CARRARD ^[19] ; Manoela Domingues MARTINS ^[20] ; Sebastião Silvério SOUSA-NETO ^[21] ; Diego Antônio Costa ARANTES ^[22] ; Elismauro Francisco MENDONÇA ^[23] ; Silvia Roberta CIESLAK-SANCHES ^[24] ; Daniella Moraes ANTUNES ^[25] ; Gleyson Kleber do AMARAL-SILVA ^[26] ; Patricia Rubia MANIERI ^[27] ; Luciana Maria Pedreira RAMALHO ^[28] ; Jean Nunes DOS SANTOS ^[29] ; Augusto César Leal da Silva LEONEL ^[30] ; Danyel Elias da Cruz PEREZ ^[31] ; Hannah Carmem Carlos Ribeiro Silva VERHEUL ^[32] ; Keila Martha Amorim BARROSO ^[33] ; Flávia Luiza Santos RODRIGUES ^[34] ; Amanda Katarinny Goes GONZAGA ^[35] ; Romana Renery FERNANDES ^[36] ; Lélia Batista DE SOUZA ^[37] ; Lucas Lacerda de SOUZA ^[38] ; Flávia Sirotheau Corrêa PONTES ^[39] ; Hélder Antônio Rebelo PONTES ^[40] ; Caroline Alfaia SILVA ^[41] ; Jeconias CÂMARA ^[42] ; Tatiana Nayara LIBÓRIO-KIMURA ^[43] ; Alan Roger SANTOS-SILVA ^[44] ; Márcio Ajudarte LOPES ^[45] ; Oslei Paes de ALMEIDA ^[46] ; Mário José ROMAÑACH ^[47] ; Pablo Agustin VARGAS ^[48]

Affiliation:Show less -

^[1] Universidade Estadual de Campinas. Piracicaba Dental School. Department of Oral Diagnosis - Brasil

^[2] A. C. Camargo Cancer Center. International Research Center. Group of Epidemiology and Statistics on Cancer - Brasil

^[3] Universidade Estadual de Campinas. Piracicaba Dental School. Department of Oral Diagnosis - Brasil

^[4] Universidade Federal de Minas Gerais. School of Dentistry. Department of Oral Surgery and Pathology - Brasil

^[5] Universidade Federal de Minas Gerai. School of Dentistry. Department of Child and Adolescent Oral Health - Brasil

^[6] Universidade Federal de Minas Gerais. School of Dentistry. Department of Oral Surgery and Pathology - Brasil

^[7] Universidade de São Paulo. School of Dentistry. Department of Oral Pathology - Brasil

^[8] Universidade Federal do Rio de Janeiro. School of Dentistry. Department of Oral Diagnosis and Pathology - Brasil

^[9] Universidade Federal do Rio de Janeiro. School of Dentistry. Department of Oral Diagnosis and Pathology - Brasil

^[10] Universidade Federal do Rio de Janeiro. School of Dentistry. Department of Oral Diagnosis and Pathology - Brasil

^[11] Universidade Estadual Paulista. Institute of Science and Technology. Department of Bioscience and Oral Diagnosis - Brasil

^[12] Universidade Estadual Paulista. Institute of Science and Technology. Department of Bioscience and Oral Diagnosis - Brasil

^[13] Universidade do Estado do Rio de Janeiro. School of Dentistry. Department of Oral Pathology - Brasil

^[14] Universidade do Estado do Rio de Janeiro. School of Dentistry. Department of Oral Pathology - Brasil

^[15] Universidade do Estado do Rio de Janeiro. School of Dentistry. Department of Oral Pathology - Brasil

^[16] Universidade Federal de Santa Catarina. Department of Pathology - Brasil

^[17] Universidade Federal de Santa Catarina. Department of Pathology - Brasil

^[18] Universidade Federal do Rio Grande do Sul. School of Dentistry. Department of Oral Pathology - Brasil

^[19] Universidade Federal do Rio Grande do Sul. School of Dentistry. Department of Oral Pathology - Brasil

^[20] Universidade Federal do Rio Grande do Sul. School of Dentistry. Department of Oral Pathology - Brasil

^[21] Universidade Federal de Goiás. School of Dentistry. Department of Stomatologic Sciences - Brasil

^[22] Universidade Federal de Goiás. School of Dentistry. Department of Stomatologic Sciences - Brasil

^[23] Universidade Federal de Goiás. School of Dentistry. Department of Stomatologic Sciences - Brasil

^[24] Universidade Federal de Mato Grosso do Sul. Faculty of Dentistry - Brasil

^[25] Universidade Federal de Mato Grosso do Sul. Faculty of Dentistry - Brasil

^[26] Universidade Federal de Mato Grosso do Sul. Faculty of Dentistry - Brasil

^[27] Universidade Federal da Bahia. School of Dentistry. Laboratory of Oral and Maxillofacial Pathology - Brasil

^[28] Universidade Federal da Bahia. School of Dentistry. Laboratory of Oral and Maxillofacial Pathology - Brasil

^[29] Universidade Federal da Bahia. School of Dentistry. Laboratory of Oral and Maxillofacial Pathology - Brasil

^[30] Universidade Federal de Pernambuco. Department of Clinic and Preventive Dentistry. Oral Pathology Unit - Brasil

^[31] Universidade Federal de Pernambuco. Department of Clinic and Preventive Dentistry. Oral Pathology Unit - Brasil

^[32] Universidade Federal da Paraíba. Department of Clinic and Social Dentistry - Brasil

^[33] Universidade Federal da Paraíba. Department of Clinic and Social Dentistry - Brasil

^[34] Universidade Federal do Rio Grande do Norte. School of Dentistry. Department of Oral Pathology - Brasil

^[35] Universidade Federal do Rio Grande do Norte. School of Dentistry. Department of Oral Pathology - Brasil

^[36] Universidade Federal do Rio Grande do Norte. School of Dentistry. Department of Oral Pathology - Brasil

^[37] Universidade Federal do Rio Grande do Norte. School of Dentistry. Department of Oral Pathology - Brasil

^[38] Universidade Federal do Pará. João de Barros Barreto University Hospital. Service of Oral Pathology - Brasil

^[39] Universidade Federal do Pará. João de Barros Barreto University Hospital. Service of Oral Pathology - Brasil

^[40] Universidade Federal do Pará. João de Barros Barreto University Hospital. Service of Oral Pathology - Brasil

^[41] Universidade Federal do Amazonas. School of Medicine. Department of Pathology and Legal Medicine - Brasil

^[42] Universidade Federal do Amazonas. School of Medicine. Department of Pathology and Legal Medicine - Brasil

^[43] Universidade Federal do Amazonas. School of Medicine. Department of Pathology and Legal Medicine - Brasil

^[44] Universidade Estadual de Campinas. Piracicaba Dental School. Department of Oral Diagnosis - Brasil

^[45] Universidade Estadual de Campinas. Piracicaba Dental School. Department of Oral Diagnosis - Brasil

^[46] Universidade Estadual de Campinas. Piracicaba Dental School. Department of Oral Diagnosis - Brasil

^[47] Universidade Federal do Rio de Janeiro. School of Dentistry. Department of Oral Diagnosis and Pathology - Brasil

^[48] Universidade Estadual de Campinas. Piracicaba Dental School. Department of Oral Diagnosis - Brasil

• Document type: Journal article
• Source: Brazilian Oral Research; v. 37, 2023-12-15.

Abstract

Abstract This study aimed to evaluate the contribution of oral and maxillofacial pathology laboratories (OMPLs) in Brazilian public universities to the diagnosis of lip, oral cavity, and oropharyngeal squamous cell carcinoma (SCC). A cross-sectional study was performed using biopsy records from a consortium of sixteen public OMPLs from all regions of Brazil (North, Northeast, Central-West, Southeast, and South). Clinical and demographic data of patients diagnosed with lip, oral cavity, and oropharyngeal SCC between 2010 and 2019 were collected from the patients’ histopathological records. Of the 120,010 oral and maxillofacial biopsies (2010-2019), 6.9% (8,321 cases) were diagnosed as lip (0.8%, 951 cases), oral cavity (4.9%, 5,971 cases), and oropharyngeal (1.2%, 1,399 cases) SCCs. Most cases were from Brazil’s Southeast (64.5%), where six of the OMPLs analyzed are located. The predominant profile of patients with lip and oral cavity SCC was Caucasian men, with a mean age over 60 years, low schooling level, and a previous history of heavy tobacco consumption. In the oropharyngeal group, the majority were non-Caucasian men, with a mean age under 60 years, had a low education level, and were former/current tobacco and alcohol users. According to data from the Brazilian National Cancer Institute, approximately 9.9% of the total lip, oral cavity, and oropharyngeal SCCs reported over the last decade in Brazil may have been diagnosed at the OMPLs included in the current study. Therefore, this data confirms the contribution of public OMPLs with respect to the important diagnostic support they provide to the oral healthcare services extended by the Brazilian Public Health System. (AU)

• FAPESP's process: 22/01257-4 - Disrupting tumor resistance through therapy targeting depletion of Cancer Stem Cells in Head and Neck Squamous Cell Carcinoma patient-derived xenograft
• Grantee: Brendo Vinicius Rodrigues Louredo
• Support Opportunities: Scholarships in Brazil - Doctorate