Risk factors for executive function impairment in adolescence: an analysis of data from the 2004 Pelotas Birth Cohort study

Author(s)

Júlia de Souza Rodrigues ; Alicia Matijasevich ^[2] ; Luciana Tovo-Rodrigues ^[3] ; Tiago N. Munhoz ; Iná S. Santos ^[5] ; Maria Pastor-Valero

• Document type: Journal article
• Source: Revista Brasileira de Psiquiatria; v. 45, n. 6, p. 470-481, 2024-02-12.

Abstract

Objective: To investigate risk factors associated with impaired attention-related executive functions (EFs) at age 11 and working memory at age 15. Methods: Data from participants of the population-based 2004 Pelotas Birth Cohort at ages 11 (n=3,582) and 15 (n=1,950) were analyzed. The study measured attentional control, cognitive flexibility, and selective attention using the Test of Everyday Attention for Children (TEA-Ch). Spatial working memory was assessed by the Cambridge Neuropsychological Test Automated Battery (CANTAB). Logistic regression was employed to explore the relationship between perinatal and childhood exposures and EF impairment. Results: Low maternal education had a significant negative impact on EFs. At age 11, it was associated with decreased attentional control (OR = 3.04; 95%CI 2.09-4.43), and at age 15, it was linked to impaired spatial working memory (OR = 2.21; 95%CI 1.58-3.09). Additional risk factors included low household income, black or brown maternal skin color, high parity, prematurity, low birth weight, and multiple siblings. Breastfeeding, regardless of duration, was found to be a protective factor against impaired cognitive flexibility (OR = 0.38; 95%CI 0.22-0.65). Conclusion: This study underscores the lasting impact of perinatal exposures on EF development. Policies that mitigate the negative effects of risk factors and promote EF development, especially among vulnerable populations, are needed. (AU)

• FAPESP's process: 20/07730-8 - Impact of social distancing measures in the COVID-19 pandemic on the mental health of adolescents belonging to a birth cohort
• Grantee: Alicia Matijasevich Manitto
• Support Opportunities: Regular Research Grants
• FAPESP's process: 20/13425-3 - Risk and protection factors for the development of executive functions in adolescence: Pelotas 2004 birth cohort
• Grantee: Julia de Souza Rodrigues
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
• FAPESP's process: 14/13864-6 - Mental disorders, substance use and executive functions in early adolescence in a birth cohort
• Grantee: Alicia Matijasevich Manitto
• Support Opportunities: Regular Research Grants