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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Ethanol consumption and pineal melatonin daily profile in rats

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Peres, Rafael [1] ; do Amaral, Fernanda Gaspar [1] ; Madrigrano, Thiago Cardoso [1] ; Scialfa, Julieta Helena [1] ; Bordin, Silvana [1] ; Afeche, Solange Castro ; Cipolla-Neto, Jose [1]
Total Authors: 7
[1] Univ Sao Paulo, Dept Physiol & Biophys, Inst Biomed Sci, BR-05508900 Sao Paulo - Brazil
Total Affiliations: 1
Document type: Journal article
Source: ADDICTION BIOLOGY; v. 16, n. 4, p. 580-590, OCT 2011.
Web of Science Citations: 15

It is well known that melatonin participates in the regulation of many important physiological functions such as sleep-wakefulness cycle, motor coordination and neural plasticity, and cognition. However, as there are contradictory results regarding the melatonin production diurnal profile under alcohol consumption, the aim of this paper was to study the phenomenology and mechanisms of the putative modifications on the daily profile of melatonin production in rats submitted to chronic alcohol intake. The present results show that rats receiving 10% ethanol in drinking water for 35 days display an altered daily profile of melatonin production, with a phase delay and a reduction in the nocturnal peak. This can be partially explained by a loss of the daily rhythm and the 25% reduction in tryptophan hydroxylase activity and, mainly, by a phase delay in arylalkylamine N-acetyltransferase gene expression and a 70% reduction in its peak activity. Upstream in the melatonin synthesis pathway, the results showed that noradrenergic signaling is impaired as well, with a decrease in beta 1 and alpha 1 adrenergic receptors' mRNA contents and in vitro sustained loss of noradrenergic-stimulated melatonin production by glands from alcohol-treated rats. Together, these results confirm the alterations in the daily melatonin profile of alcoholic rats and suggest the possible mechanisms for the observed melatonin synthesis modification. (AU)

FAPESP's process: 04/06767-2 - Melatonin and the control of energy metabolism: central and peripheral actions and their interaction with other hormones
Grantee:José Cipolla Neto
Support type: Research Projects - Thematic Grants