Advanced search
Start date
Betweenand
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

The use of joint-specific and whole-body MRI in osteonecrosis: a study in patients with juvenile systemic lupus erythematosus

Full text
Author(s):
Castro, T. C. M. [1] ; Lederman, H. [2] ; Terreri, M. T. A. [1] ; Caldana, W. I. [2] ; Kaste, S. C. [3] ; Hilario, M. O. [1]
Total Authors: 6
Affiliation:
[1] Univ Fed Sao Paulo, Div Allergy Clin Immunol & Rheumatol, Dept Pediat, BR-04025002 Sao Paulo - Brazil
[2] Univ Fed Sao Paulo, Dept Diagnost Imaging, BR-04025002 Sao Paulo - Brazil
[3] Univ Tennessee, Coll Med, Div Diagnost Imaging, Dept Radiol Sci, Knoxville, TN 37996 - USA
Total Affiliations: 3
Document type: Journal article
Source: British Journal of Radiology; v. 84, n. 1003, p. 621-628, JUL 2011.
Web of Science Citations: 10
Abstract

Objective: This study aimed to estimate the prevalence of osteonecrosis (ON) in juvenile systemic lupus erythematosus (SLE) patients using joint-specific and whole-body MRI; to explore risk factors that are associated with the development of ON; and to evaluate prospectively patients 1 year after initial imaging. Method: Within a 2 year period, we studied 40 juvenile SLE patients (aged 8-18 years) with a history of steroid use of more than 3 months duration. Risk factors including disease activity, corticosteroid use, vasculitis, Raynaud's phenomenon and lipid profile were evaluated. All patients underwent MRI of the hips, knees and ankles using joint-specific MRI. Whole-body STIR (short tau inversion recovery) MRI was performed in all patients with ON lesions. Results: Osteonecrosis was identified in 7 patients (17.5 %) upon joint-specific MRI. Whole-body STIR MRI detected ON in 6 of these 7 patients. There was no significant difference between the ON and non-ON groups in the risk factors studied. One patient had pre-existing symptomatic ON. At 1 year follow-up, the ON lesions had resolved in one patient, remained stable in four and decreased in size in two. No asymptomatic patients with ON developed clinical manifestations. Conclusion: Whole-body STIR MRI may be useful in detecting ON lesions in juvenile SLE patients but larger studies are needed to define its role. (AU)