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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

The use of joint-specific and whole-body MRI in osteonecrosis: a study in patients with juvenile systemic lupus erythematosus

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Author(s):
Castro, T. C. M. [1] ; Lederman, H. [2] ; Terreri, M. T. A. [1] ; Caldana, W. I. [2] ; Kaste, S. C. [3] ; Hilario, M. O. [1]
Total Authors: 6
Affiliation:
[1] Univ Fed Sao Paulo, Div Allergy Clin Immunol & Rheumatol, Dept Pediat, BR-04025002 Sao Paulo - Brazil
[2] Univ Fed Sao Paulo, Dept Diagnost Imaging, BR-04025002 Sao Paulo - Brazil
[3] Univ Tennessee, Coll Med, Div Diagnost Imaging, Dept Radiol Sci, Knoxville, TN 37996 - USA
Total Affiliations: 3
Document type: Journal article
Source: British Journal of Radiology; v. 84, n. 1003, p. 621-628, JUL 2011.
Web of Science Citations: 10
Abstract

Objective: This study aimed to estimate the prevalence of osteonecrosis (ON) in juvenile systemic lupus erythematosus (SLE) patients using joint-specific and whole-body MRI; to explore risk factors that are associated with the development of ON; and to evaluate prospectively patients 1 year after initial imaging. Method: Within a 2 year period, we studied 40 juvenile SLE patients (aged 8-18 years) with a history of steroid use of more than 3 months duration. Risk factors including disease activity, corticosteroid use, vasculitis, Raynaud's phenomenon and lipid profile were evaluated. All patients underwent MRI of the hips, knees and ankles using joint-specific MRI. Whole-body STIR (short tau inversion recovery) MRI was performed in all patients with ON lesions. Results: Osteonecrosis was identified in 7 patients (17.5 %) upon joint-specific MRI. Whole-body STIR MRI detected ON in 6 of these 7 patients. There was no significant difference between the ON and non-ON groups in the risk factors studied. One patient had pre-existing symptomatic ON. At 1 year follow-up, the ON lesions had resolved in one patient, remained stable in four and decreased in size in two. No asymptomatic patients with ON developed clinical manifestations. Conclusion: Whole-body STIR MRI may be useful in detecting ON lesions in juvenile SLE patients but larger studies are needed to define its role. (AU)