| Full text | |
| Author(s): Show less - |
Daher, Isabela Pazotti
;
Almeida, Bianca da Silva
;
de Souza-Silva, Guilherme Antonio
;
Marques, Rodolfo Ferreira
;
Soares, Gustavo Henrique Correa
;
Andreata-Santos, Robert
;
Moretti, Ana
;
Silva, Mariangela de Oliveira
;
Schuch, Viviane
;
Sasahara, Greyce Luri
;
Kuramoto, Andreia
;
Yamamoto, Marcio
;
Ferreira, Luis Carlos de Souza
;
Santos, Keity
;
Coelho, Veronica P. C. V.
;
Kalil, Jorge
;
Rosa, Daniela Santoro
;
Cunha-Neto, Edecio
;
Boscardin, Silvia Beatriz
Total Authors: 19
|
| Document type: | Journal article |
| Source: | Clinical Immunology; v. 276, p. 12-pg., 2025-07-01. |
| Abstract | |
The emergence of SARS-CoV-2 variants has reduced antibody effectiveness, affecting vaccine protection. This study evaluated neutralizing antibodies against Wuhan strain and several variants, including Alpha, Beta, Gamma, Delta, and Omicron, in Brazilians vaccinated twice with CoronaVac, ChAdOx1-S, or BNT162b2 before Delta and Omicron emerged. After the booster, strong antibody responses to the Wuhan strain were seen in all groups, but BNT162b2 resulted in higher anti-Spike and anti-RBD IgG levels. While all vaccines showed some cross-neutralization against Alpha, Beta, Gamma, and Delta, only BNT162b2 was effective against Omicron BA.2 and BA.4/5 subvariants. Furthermore, BNT162b2 vaccination showed a positive correlation between Wuhan RBD-specific IgG and Omicron neutralizing antibodies. This group demonstrated distinct clustering patterns of neutralizing antibodies against all variants, unlike those from CoronaVac and ChAdOx1-S. The findings suggest BNT162b2 offers broader neutralization capability, highlighting the benefit of booster shots with bivalent mRNA vaccines to enhance immune responses against emerging variants. (AU) | |
| FAPESP's process: | 21/14197-7 - Neutralizing antibodies against different SARS-CoV-2 variants of concern in convalescent and immunized individuals with different COVID-19 vaccines |
| Grantee: | Isabela Pazotti Daher |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 14/50890-5 - INCT of Investigation in Immunology |
| Grantee: | Jorge Elias Kalil Filho |
| Support Opportunities: | Research Projects - Thematic Grants |
| FAPESP's process: | 21/13004-0 - Development of subunit vaccines against SARS-CoV-2 based on the receptor binding domain (RBD) |
| Grantee: | Daniela Santoro Rosa |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 18/07142-9 - Influence of STAT1, STAT3, STAT5 and STAT6 Signaling Pathways on Conventional Dendritic Cells in the Instruction of the T-Cell Auxiliary Response |
| Grantee: | Silvia Beatriz Boscardin |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 20/05204-7 - Development of SARS-CoV-2 auto-assembly protein-based nanovaccines |
| Grantee: | Luis Carlos de Souza Ferreira |
| Support Opportunities: | Regular Research Grants |