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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

New Roles for Innate Immune Response in Acute and Chronic Kidney Injuries

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Goncalves, G. M. ; Castoldi, A. [1] ; Braga, T. T. ; Camara, N. O. S. [1, 2]
Total Authors: 4
[1] Univ Fed Sao Paulo, Escola Paulista Med, Div Nephrol, Lab Clin & Expt Immunol, Sao Paulo - Brazil
[2] Univ Sao Paulo, Inst Biomed Sci 4, Dept Immunol, Lab Transplantat Immunobiol, BR-05508900 Sao Paulo - Brazil
Total Affiliations: 2
Document type: Review article
Source: Scandinavian Journal of Immunology; v. 73, n. 5, p. 428-435, MAY 2011.
Web of Science Citations: 29

The innate immune system plays an important role as a first response to tissue injury. This first response is carried out via germline-encoded receptors. They can recognize exogenous Pathogen-Associated Molecular Patterns and endogenous Dangers-Associated Molecular Patterns. The Toll-Like Receptor (TLR) family is well-studied, but more recently another family in the cytoplasmic compartment, called nod-like receptor (NLR), was discovered. In addition to being present in inflammatory cells, these receptors are widely distributed in various cell types, including renal tissue, where these receptors have an important role in triggering the inflammatory response during renal diseases. This review summarizes the present data regarding the role of TLRs and NLRs in the course and development of various kidney pathologies. (AU)

FAPESP's process: 07/07139-3 - The role of heme oxygenase 1 in different renal inflammatory process in experimental animal models
Grantee:Niels Olsen Saraiva Câmara
Support type: Research Projects - Thematic Grants