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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Analysis of vitamin D receptor gene polymorphisms in women with and without endometriosis

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Vilarino, Fabia Lima [1] ; Bianco, Bianca [1] ; Lerner, Tatiana Goberstein [1] ; Teles, Juliana Souto [1] ; Mafra, Fernanda Abani [1] ; Christofolini, Denise Maria [1] ; Barbosa, Caio Parente [1]
Total Authors: 7
[1] ABC, Fac Med, Dept Gynecol & Obstet, Div Pathol Gynecol & Human Reprod, Santo Andre Sao Paulo - Brazil
Total Affiliations: 1
Document type: Journal article
Source: HUMAN IMMUNOLOGY; v. 72, n. 4, p. 359-363, APR 2011.
Web of Science Citations: 22

An aberrant immunologic mechanism has been suggested to be involved in the pathogenesis of endometriosis. Genetic alterations in the vitamin D receptor gene (VDR) may lead to important defects in gene activation that principally affect immune function. We have hypothesized a possible relationship between endometriosis and/or infertility and the VDR polymorphisms (Apal, Taql, Fokl, and Bats!). The study was a case-control study including 132 women with endometriosis-related infertility, 62 women with idiopathic infertility, and 133 controls. VDR polymorphisms were studied by restriction fragment length polymorphism. We found relatively similar VDR polymorphism genotype frequencies in cases and controls. When patients with minimal/mild and moderate/severe endometriosis were studied separately, no difference was found. When we compared infertile groups with and without endometriosis there was no statistically significant difference. The data suggest that VDR polymorphisms did not play an important role in the pathogenesis of endometriosis and/or infertility in the Brazilian women studied. (C) 2011 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved. (AU)

Grantee:Juliana Souto Teles
Support type: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 10/01104-6 - Study of Fok1 polymorphism of VDR gene in women with endometriosis
Grantee:Tatiana Goberstein Lerner
Support type: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 10/00459-5 - Evaluation of VDR polymorphism in women with endometriosis
Grantee:Caio Parente Barbosa
Support type: Regular Research Grants