Bunodosine 391: An Analgesic Acylamino Acid from t... - BV FAPESP
Advanced search
Start date
Betweenand
Related content
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Bunodosine 391: An Analgesic Acylamino Acid from the Venom of the Sea Anemone Bunodosoma cangicum

Full text
Author(s):
Zaharenko, Andre J. [1, 2] ; Picolo, Gisele [3] ; Ferreira, Jr., Wilson A. [4, 3] ; Murakami, Takanori [5, 6] ; Kazuma, Kohei [7] ; Hashimoto, Masaru [5, 6] ; Cury, Yara [3] ; de Freitas, Jose C. [4] ; Satake, Motoyoshi [7] ; Konno, Katsuhiro [7]
Total Authors: 10
Affiliation:
[1] Butantan Inst, Genet Lab, BR-05503900 Sao Paulo - Brazil
[2] Nucl & Energy Res Inst, Ctr Biotechnol, BR-05508000 Sao Paulo - Brazil
[3] Butantan Inst, Lab Pain & Signaling, BR-05503900 Sao Paulo - Brazil
[4] Univ Sao Paulo, Inst Biosci, BR-05508900 Sao Paulo - Brazil
[5] Iwate Univ, United Grad Sch Agr Sci, Hirosaki, Aomori 0368561 - Japan
[6] Hirosaki Univ, Fac Agr & Life Sci, Hirosaki, Aomori 0368561 - Japan
[7] Toyama Univ, Inst Nat Med, Toyama 9300194 - Japan
Total Affiliations: 7
Document type: Journal article
Source: Journal of Natural Products; v. 74, n. 3, p. 378-382, MAR 2011.
Web of Science Citations: 18
Abstract

A new acylamino acid, bunodosine 391 (BDS 391), was isolated from the venom of the sea anemone Bunodosoma cangicum. The structure was elucidated by spectroscopic analyses (2D NMR, ESIMS/MS) and verified by its synthesis. Intraplantar injection of BDS 391 into the hind paw of a rat induced a potent analgesic effect. This effect was not altered by naloxone (an opioid receptor antagonist), but was completely reversed by methysergide (a serotonin receptor antagonist), indicating that the effect is mediated by activation of serotonin receptors: (AU)

FAPESP's process: 08/01988-1 - Characterization of the molecular action of Bunodosine 391, an analgesic compound isolated from the venom of sea anemone Bunodosoma cangicum
Grantee:Wilson Alves Ferreira Júnior
Support Opportunities: Scholarships in Brazil - Master
FAPESP's process: 09/08089-5 - Molecular mechanisms involved in the analgesic action of the compound Bunodosina 391 isolated from Bunodosoma cangicum sea anemone venom
Grantee:Yara Cury
Support Opportunities: Regular Research Grants