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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Secondary PSF/TFE3-associated renal cell carcinoma in a child treated for genitourinary rhabdomyosarcoma

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Author(s):
Brassesco, Maria Sol [1] ; Valera, Elvis Terci [1] ; Bonilha, Thais Alcantara [1] ; Scrideli, Carlos Alberto [1] ; de Oliveira, Jaqueline Carvalho [2] ; Pezuk, Julia Alejandra [2] ; Barros Silva, Gyl Eanes [3] ; Costa, Roberto Silva [3] ; Tone, Luiz Gonzaga [1]
Total Authors: 9
Affiliation:
[1] Univ Sao Paulo, Dept Pediat, Div Pediat Oncol, Sao Paulo - Brazil
[2] Univ Sao Paulo, Dept Genet, Sao Paulo - Brazil
[3] Univ Sao Paulo, Dept Pathol, Fac Med Ribeirao Preto, Sao Paulo - Brazil
Total Affiliations: 3
Document type: Journal article
Source: CANCER GENETICS; v. 204, n. 2, p. 108-110, FEB 2011.
Web of Science Citations: 10
Abstract

Xp11.2 translocation-associated renal cell carcinoma (RCC) is a rare tumor that accounts for at least one-third of childhood RCC. Different reports have emphasized that previous radio/chemotherapy might be involved in its pathogenesis. We describe a child who developed a t(X;1) (p11.2;p34) associated RCC after previous treatment for genitourinary rhabdomyosarcoma in infancy. The presence of the PSF-TFE3 fusion has only been described in a very limited number of cases. Our report expands the spectrum of tumors in which RCC can arise in the pediatric age group after chemotherapy. (AU)