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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Mucoepidermoid Carcinoma of the Lung Arising at the Primary Site of A Bronchogenic Cyst: Clinical, Cytogenetic, and Molecular Findings

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Author(s):
Brassesco, Maria Sol [1] ; Valera, Elvis Terci [1] ; Peixoto Lira, Regia Caroline [1] ; Torres, Lidia Alice Gomes M. [2] ; Scrideli, Carlos Alberto [1] ; Elias, Jr., Jorge [3, 4] ; Teixeira, Sara Reis [3, 4] ; Tone, Luiz Gonzaga [1]
Total Authors: 8
Affiliation:
[1] Univ Sao Paulo, Div Pediat Oncol, BR-05508 Sao Paulo - Brazil
[2] Univ Sao Paulo, Dept Pediat, Div Pediat Pneumol, BR-05508 Sao Paulo - Brazil
[3] Univ Sao Paulo, Fac Med Ribeirao Preto, BR-05508 Sao Paulo - Brazil
[4] Univ Sao Paulo, Div Radiol, BR-05508 Sao Paulo - Brazil
Total Affiliations: 4
Document type: Journal article
Source: PEDIATRIC BLOOD & CANCER; v. 56, n. 2, p. 311-313, FEB 2011.
Web of Science Citations: 7
Abstract

Primary lung tumors are rare in children, and mucoepidermoid carcinoma (MEC) represents less than 10% of them. Additionally, MEC arising from bronchogenic cysts (BC) is particularly unusual. We describe the clinical and genetic findings on a MEC occurring within a previous location of a BC in an adolescent. This particular association has not been previously reported. The lesion revealed normal karyotype without the typical t(11;19)(q21;p13) translocation. Cyclin D1 overexpression (165-fold increase) was demonstrated by real-time PCR although FISH assessment showed normal hybridization at 11q13. Information on these unusual clinical presentations may present relevant insight on tumorigenesis of infrequent pediatric pulmonary tumors. Pediatr Blood Cancer 2011;56:311-313. (C) 2010 Wiley-Liss, Inc. (AU)