Analytical Potentialities of Carbon Nanotube/Silicone Rubber Composite Electrodes: Determination of Propranolol

Author(s)

dos Santos, Sidney Xavier ^{[1, 2]} ; Cavalheiro, Eder T. G. ^[1] ; Brett, Christopher M. A. ^[2]

Affiliation

^[1] Univ Sao Paulo, Dept Quim & Fis Mol, Inst Quim Sao Carlos, BR-13560970 Sao Carlos, SP - Brazil

^[2] Univ Coimbra, Dept Quim, Fac Ciencias & Tecnol, P-3004535 Coimbra - Portugal

• Document type: Journal article
• Source: Electroanalysis; v. 22, n. 23, p. 2776-2783, DEC 2010.
• Web of Science Citations: 12

Abstract

A new composite electrode based on multiwall carbon nanotubes (MWCNT) and silicone-rubber (SR) was developed and applied to the determination of propranolol in pharmaceutical formulations. The effect of using MWCNT/graphite mixtures in different proportions was also investigated. Cyclic voltammetry and electrochemical impedance spectroscopy were used for electrochemical characterization of different electrode compositions. Propranolol was determined using MWCNT/SR 70% (m/m) electrodes with linear dynamic ranges up to 7.0 mu molL(-1) by differential pulse and up to 5.4 mu molL(-1) by square wave voltammetry, with LODs of 0.12 and 0.078 mu molL(-1), respectively. Analysis of commercial samples agreed with that obtained by the official spectrophotometric method. The electrode is mechanically robust and presented reproducible results and a long useful life. (AU)

• FAPESP's process: 08/03537-7 - Development and application of composite electrodes based on graphite-poliurethane and graphite-silicone rubber-III: modification with carbon nanotubes and molecularly imprinted polymers
• Grantee: Éder Tadeu Gomes Cavalheiro
• Support Opportunities: Regular Research Grants