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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Oral tolerance reduces Th17 cells as well as the overall inflammation in the central nervous system of EAE mice

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Author(s):
Peron, Jean Pierre S. [1] ; Yang, Kayong [2] ; Chen, Mei-Ling [2] ; Brandao, Wesley Nogueira [1] ; Basso, Alexandre S. [3] ; Commodaro, Alessandra G. [1] ; Weiner, Howard L. [2] ; Rizzo, Luiz V. [1, 4]
Total Authors: 8
Affiliation:
[1] Univ Sao Paulo, Inst Biomed Sci, Clin Immunol Lab, BR-05508900 Sao Paulo - Brazil
[2] Harvard Univ, Brigham & Womens Hosp, Sch Med, Ctr Neurol Dis, Boston, MA 02115 - USA
[3] Univ Fed Sao Paulo, UNIFESP, Dept Microbiol Immunol & Parasitol, BR-04023062 Sao Paulo - Brazil
[4] Albert Einstein Jewish Inst Educ & Res, BR-056519 Sao Paulo - Brazil
Total Affiliations: 4
Document type: Journal article
Source: Journal of Neuroimmunology; v. 227, n. 1-2, p. 10-17, OCT 8 2010.
Web of Science Citations: 39
Abstract

Multiple sclerosis (MS) is an autoimmune disease characterized by inflammatory immune response directed against myelin antigens of the central nervous system. In its murine model, EAE, Th17 cells play an important role in disease pathogenesis. These cells can induce blood-brain barrier disruption and CNS immune cells activation, due to the capacity to secrete high levels of IL-17 and IL-22 in an IL-6 + TGF-beta dependent manner. Thus, using the oral tolerance model, by which 200 mu g of MOG 35-55 is given orally to C57BL/6 mice prior to immunization, we showed that the percentage of Th17 cells as well as IL-17 secretion is reduced both in the periphery and also in the CNS of orally tolerated animals. Altogether, our data corroborates with the pathogenic role of IL-17 and IFN-gamma in EAE, as its reduction after oral tolerance, leads to an overall reduction of pro-inflammatory cytokines, such as IL-1 alpha, IL-6, IL-9, IL-12p70 and the chemokines MIP-1 beta, RANTES, Eotaxin and KC in the CNS. It is noteworthy that this was associated to an increase in IL-10 levels. Thus, our data clearly show that disease suppression after oral tolerance induction, correlates with reduction in target organ inflammation, that may be caused by a reduced Th1/Th17 response. Crown Copyright (c) 2010 Published by Elsevier B.V. All rights reserved. (AU)

FAPESP's process: 09/13109-5 - Relationship between the cytokine profile of In vitro activated microglial cells and the generation of the pathogenic th17 cells
Grantee:Wesley Nogueira Brandão
Support type: Scholarships in Brazil - Master