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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Lipoic acid effects on renal function, aminopeptidase activities and oxidative stress in Crotalus durissus terrificus envenomation in mice

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Alegre, Valter de Sousa [1] ; Barone, Juliana Marton [1] ; Yamasaki, Simone Cristina [1] ; Zambotti-Villela, Leonardo [1] ; Silveira, Paulo Flavio [1]
Total Authors: 5
[1] Inst Butantan, Pharmacol Lab, BR-05503900 Sao Paulo - Brazil
Total Affiliations: 1
Document type: Journal article
Source: Toxicon; v. 56, n. 3, p. 402-410, SEP 1 2010.
Web of Science Citations: 11

Crotalus durissus terrificus envenomation has been associated with direct nephrotoxicity, rhabdomyolysis, hyperuricemia, urinary hypoosmolality, alterations in aminopeptidase activities (AP) and oxidative stress. This study evaluated the effects of lipoic acid (LA) on renal function, lethality, AP and GSSG/GSH in mice injected with C. d. terrificus venom (vCdt). The doses and routes of administration of LA and vCdt promoted no systemic myotoxicity. LA did not alter significantly the lethality of vCdt. In nonenvenomed, LA induced hypercreatinemia, urinary hyperosmolality, decrease of urinary urea and creatinine, increase of protein in plasma and in soluble fraction (SF) and decrease in membrane-bound fraction (MF) of cortex and medulla. Decreased levels of all AP (except neutral-AP in MF-medulla) were also induced by LA in nonenvenomed. LA associated with vCdt decreased plasma osmolality, hematocrit, urinary uric acid, but increased urinary and SF-medullar protein. LA mitigated the increase of protein in SF-cortex and corrected hyperuricemia, GSSG/GSH and protein in MF-cortex and MF-medulla, as well as decreased plasma neutral AP and acid AP in MF-medulla of envenomed mice. Data suggest that LA contributes to the solubilization/remotion of proteins in MF with impairment of most AP, but it could be beneficial for the treatment of the direct nephrotoxicity of vCdt. (C) 2010 Elsevier Ltd. All rights reserved. (AU)

FAPESP's process: 06/06926-9 - Plasma, urinary and renal aminopeptidases in mice injected with Bothrops jararaca and Crotalus durissus terrificus venoms
Grantee:Paulo Flávio Silveira
Support Opportunities: Regular Research Grants