| Full text | |
| Author(s): |
Beltrao, Cristine B.
[1, 2]
;
Juliano, Adriana G.
[3]
;
Chammas, Maria C.
[3]
;
Watanabe, Tomoco
[3]
;
Sapienza, Marcelo T.
[3]
;
Marui, Suemi
[1]
Total Authors: 6
|
| Affiliation: | [1] Univ Sao Paulo, Lab Endocrinol Celular & Mol, LIM 25, Hosp Clin, Fac Med, BR-01246903 Sao Paulo - Brazil
[2] APAE Sao Caetano Sul, Assoc Pais & Amigos Excepc, Sao Paulo - Brazil
[3] Univ Sao Paulo, Dept Radiol, InRAD, Fac Med, BR-01246903 Sao Paulo - Brazil
Total Affiliations: 3
|
| Document type: | Journal article |
| Source: | ENDOCRINE JOURNAL; v. 57, n. 7, p. 587-593, JUL 2010. |
| Web of Science Citations: | 10 |
| Abstract | |
Methods currently employed to establish the etiology of congenital hypothyroidism include thyroid ultrasound and scintigraphic exams. Thyroglobulin is a protein almost exclusively secreted by thyroid tissue and indirectly reflects the amount of follicular cells. Even though thyroglobulin is easy to measure, it has been not frequently used because of discordant results to distinguish mainly athyreosis and ectopy (dysgenesis). Knowing the differences in inheritance and prognosis of thyroid dysgenesis and dyshormonogenesis, it is important to define the etiology of CH, combining tools that are easy, fast and available in most medical centers. Our objective was to evaluate and compare color Doppler ultrasound and serum thyroglobulin with radionuclide scan to define the etiology of congenital hypothyroidism. We evaluated 38 children above 3 years-old off-treatment that performed serum thyroglobulin by immunofluorometric assay, color Doppler ultrasound and radionuclide study. On color Doppler ultrasound, 11 patients had athyreosis, 5 ectopic glands, being I associated to hemiagenesis. Twenty one had topic thyroid (3 goiters, 10 normal, 8 hypoplastic). Hemiagenesis and cystic lesion were not revealed by radionuclide scan. We observed substantial agreement between color Doppler ultrasound and radionuclide scan (kappa=0.745, p<0.0001). Serum thyroglobulin in athyreosis ranged from <1.0 to 18.7 mu g/L. Patients with ectopic glands showed wider thyroglobulin range (4.5 to 123 mu g/L, median 28.4 mu g/L). Only one patient showed thyroglobulin deficiency. By using color Doppler ultrasound and serum thyroglobulin levels as valuable combined tools, we established the etiology of congenital hypothyroidism limiting excessive and harmful exams in children, like radionuclide scan. (AU) | |
| FAPESP's process: | 06/05800-1 - Study of mutations in PAX-8 and TSH receptor genes after determination of congenital hypothyroidism etiology: importance of color Doppler ultrasonography, thyroid uptake and scan and intravenous perchlorate test |
| Grantee: | Suemi Marui |
| Support Opportunities: | Regular Research Grants |