Advanced search
Start date
Betweenand
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Family-based association study for bipolar affective disorder

Full text
Author(s):
Secolin, Rodrigo ; Banzato, Claudio E. M. [1] ; Oliveira, Maria C. M. [1] ; Bittar, Maria F. R. ; Santos, Marilza L. ; Dalgalarrondo, Paulo [1] ; Lopes-Cendes, Iscia [2]
Total Authors: 7
Affiliation:
[1] Univ Estadual Campinas, Dept Med Psychol & Psychiat, BR-13084971 Campinas, SP - Brazil
[2] Univ Estadual Campinas, FCM, Dept Med Genet, BR-13084971 Campinas, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: PSYCHIATRIC GENETICS; v. 20, n. 3, p. 126-129, JUN 2010.
Web of Science Citations: 5
Abstract

In this study we aimed to evaluate 21 candidate loci for bipolar affective disorder (BPAD) identified earlier in a large genome-wide association study. We evaluated 74 pedigrees with BPAD, with a total of 411 individuals, including 96 patients who fulfilled clinical criteria for BPAD according to Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition classification. Family-based association analysis was performed using the UNPHASED software. We identified a single nucleotide polymorphism (rs9834970) localized on chromosome 3p22.3, showing statistically significant association with BPAD after the Bonferroni correction for multiple comparisons (P(corrected)=0.0025) with an odds ratio = 2.64 (95% confidence interval: 1.30-5.35). Single nucleotide polymorphism rs9834970 is located in an intergenic region and is not known to be associated to regulatory genomic sequences. Psychiatr Genet 20:126-129 (C) 2010 Wolters Kluwer Health vertical bar Lippincott Williams \& Wilkins. (AU)