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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Transcriptome analysis of nicotine-exposed cells from the brainstem of neonate spontaneously hypertensive and Wistar Kyoto rats

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Author(s):
Ferrari, M. F. R. [1] ; Reis, E. M. [2] ; Matsumoto, J. P. P. [3] ; Fior-Chadi, D. R. [3]
Total Authors: 4
Affiliation:
[1] Univ Sao Paulo, Dept Neurol, Fac Med, BR-01246903 Sao Paulo - Brazil
[2] Univ Sao Paulo, Inst Quim, Dept Bioquim, BR-01246903 Sao Paulo - Brazil
[3] Univ Sao Paulo, Inst Biociencias, Dept Fisiol, BR-01246903 Sao Paulo - Brazil
Total Affiliations: 3
Document type: Journal article
Source: PHARMACOGENOMICS JOURNAL; v. 10, n. 2, p. 134-160, APR 2010.
Web of Science Citations: 2
Abstract

In this study, the effects of nicotine on global gene expression of cultured cells from the brainstem of spontaneously hypertensive rat (SHR) and normotensive Wistar Kyoto (WKY) rats were evaluated using whole-genome oligoarrays. We found that nicotine may act differentially on the gene expression profiles of SHR and WKY. The influence of strain was present in 321 genes that were differentially expressed in SHR as compared with WKY brainstem cells independently of the nicotine treatment. A total of 146 genes had their expression altered in both strains after nicotine exposure. Interaction between nicotine treatment and the strain was observed to affect the expression of 229 genes that participate in cellular pathways related to neurotransmitter secretion, intracellular trafficking and cell communication, and are possibly involved in the phenotypic differentiation between SHR and WKY rats, including hypertension. Further characterization of their function in hypertension development is warranted. The Pharmacogenomics Journal (2010) 10, 134-160; doi:10.1038/tpj.2009.42; published online 15 September 2009 (AU)