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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Mechanism of Fluoride Dentifrice Effect on Enamel Demineralization

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Tenuta, L. M. A. [1] ; Zamataro, C. B. ; Del Bel Cury, A. A. ; Tabchoury, C. P. M. ; Cury, J. A.
Total Authors: 5
[1] Univ Estadual Campinas, Piracicaba Dent Sch, Fac Odontol Piracicaba, BR-13414903 Piracicaba, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Source: Caries Research; v. 43, n. 4, p. 278-285, 2009.
Web of Science Citations: 31

Although the anticaries effect of fluoride (F) dentifrices is clearly established, the relative importance of F taken up by dental plaque not removed by brushing and of F products (CaF(2)-like) formed on totally cleaned enamel for the subsequent inhibition of demineralization is not known. Both effects were evaluated using conventional (1,100 mu g F/g) and low-F concentration (500 mu g F/g) dentifrices in a randomized, crossover, double-blind in situ study. Enamel blocks not treated or pretreated with the dentifrices to form CaF(2)-like deposits were mounted in palatal appliances in contact with a Streptococcus mutans test plaque. Volunteers brushed with non-F (negative control), low-F or conventional dentifrices and inserted the appliance in the mouth. F concentration in the fluid and solid phases of the test plaque was determined after 30 min, and a rinse with 20% sucrose solution was performed. After additional 45 min, plaque was collected and the loss of surface hardness at different test-plaque depths was measured. CaF(2)-like deposition on enamel and F taken up by plaque due to the use of F dentifrices were able to significantly increase F concentration in the fluid phase of the test plaque, but only the latter significantly reduced the loss of hardness because of the 20-30 times higher F concentration. Also, significant differences between the low-F and conventional dentifrices were observed for F on enamel, in plaque and on the subsequent loss of hardness. The results suggest that uptake of F by dental plaque not removed by brushing may be the main cause of the anticaries effect of F dentifrices. Copyright (C) 2009 S. Karger AG, Basel (AU)