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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

A morphometric study on the longitudinal and lateral symmetry of the sural nerve in mature and aging female rats

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Jeronimo, Andre [1, 2] ; Dominques Jeronimo, Claudia Alem [1, 2] ; Rodrigues Filho, Omar Andrade [1] ; Sanada, Luciana Sayuri [3] ; Sassoli Fazan, Valeria Paula [4]
Total Authors: 5
[1] Univ Fed Triangulo Mineiro, Dept Biol Sci, Uberaba, MG - Brazil
[2] Univ Uberaba, Phys Therapy Course, Uberaba, MG - Brazil
[3] Univ Sao Paulo, Dept Neurol, BR-14049900 Sao Paulo - Brazil
[4] Univ Sao Paulo, Dept Surg & Anat, BR-14049900 Sao Paulo - Brazil
Total Affiliations: 4
Document type: Journal article
Source: Brain Research; v. 1222, p. 51-60, JUL 30 2008.
Web of Science Citations: 29

Aging affects peripheral nerve function and regeneration in experimental models but few literature reports deal with animals aged more than one year. We investigated morphological and morphometric aspects of the sural nerve in aging rats. Female Wistar rats 360, 640 and 720 days old were killed, proximal and distal segments of the right and left sural nerves were prepared for light microscopy and computerized morphometry. No morphometric differences between proximal and distal segments or between right and left sides at the same levels were found in all experimental groups. No increase in fiber and axon sizes was observed from 360 to 720 days. Likewise, no difference in total myelinated fiber number was observed between groups. Myelinated fiber population distribution was bimodal, being the 720-days old animals' distribution shifted to the left, indicating a reduction of the fiber diameters. The 9 ratio distribution of the 720-days old animals' myelinated fiber was also shifted to the left, which suggests axonal atrophy. Morphological alterations due to aging were observed, mainly related to the myelin sheath, which suggests demyelination. Large fibers were more affected than the smaller ones. Axon abnormalities were not as common or as obvious as the myelin changes and Wallerian degeneration was rarely found. These alterations were observed in all experimental groups but were much less pronounced in rats 360 days old and their severity increased with aging. in conclusion, the present study indicates that the aging neuropathy present in the sural nerve of female rats is both axonal and demyelinating. (C) 2008 Elsevier B.V. All rights reserved. (AU)