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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Congenital Bilateral Perisylvian Syndrome: Familial Occurrence, Clinical and Psycholinguistic Aspects Correlated with MRI

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Brandao-Almeida, I. L. [1] ; Hage, S. R. V. [2] ; Oliveira, E. R. M. ; Guimaraes, C. A. ; Teixeira, K. C. S. ; Abramides, D. V. M. [2] ; Montenegro, M. A. ; Santos, N. F. [1] ; Cendes, F. ; Lopes-Cendes, I. [1] ; Guerreiro, M. M. [3]
Total Authors: 11
[1] Univ Estadual Campinas, Dept Med Genet, BR-13083970 Campinas, SP - Brazil
[2] Univ Sao Paulo FOB, Dept Speech Pathol, Bauru, SP - Brazil
[3] Univ Estadual Campinas, Dept Neurol, FCM, BR-13083970 Campinas, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: NEUROPEDIATRICS; v. 39, n. 3, p. 139-145, JUN 2008.
Web of Science Citations: 8

Objective: Congenital bilateral perisylvian syndrome (CBPS) is frequently caused by polymicrogyria (PMG). The aim of this study was to correlate the clinical and psycholinguistic aspects with neuroradiological data of patients with CBPS. Methods: Thirty-one patients were studied. We performed a clinical investigation of the patients and their families, including MRI scanning, neuropsychological tests and language evaluation. Results: The statistical analysis showed that: a) prenatal events are associated with the non-familial type of PMG; b) diffuse PMG is associated with pseudobulbar signs, as opposed to BPPP; c) motor deficit is associated with diffuse PMG; d) epilepsy is equally present in patients with both familial or non-familial PMG, but is more frequently seen in patients with diffuse PMG; e) dyslexia and SLI can be a feature of both the diffuse or BPPP, and either familial or sporadic cases of PMG. Conclusions: The severity of clinical manifestations in CBPS is correlated with the extent of cortical involvement. Most patients with CBPS have a history of speech delay or language difficulties and no epilepsy. Dyslexia can be found in patients with PMG. (AU)