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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Evaluation of the antibacterial activity of the methylene chloride extract of Miconia ligustroides, isolated triterpene acids, and ursolic acid derivatives

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Cunha, Wilson R. [1] ; de Matos, Geilton X. [1] ; Souza, Maria Goreti M. [1] ; Tozatti, Marcos G. [1] ; Andrade E Silva, Marcio L. [1] ; Martins, Carlos H. G. [1] ; da Silva, Rosangela [1] ; da Silva Filho, Ademar A. [1]
Total Authors: 8
[1] Univ Franca, Nucleo Pesquisa Ciencias Exatas & Tecnol, BR-14404600 Franca, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Source: Pharmaceutical Biology; v. 48, n. 2, p. 166-169, FEB 2010.
Web of Science Citations: 22

The methylene chloride extract of Miconia ligustroides (DC.) Naudin (Melastomataceae), the isolated compounds ursolic and oleanolic acids and a mixture of these acids, and ursolic acid derivatives were evaluated against the following microorganisms: Bacillus cereus (ATCC 14579), Vibrio cholerae (ATCC 9458), Salmonella choleraesuis (ATCC 10708), Klebsiella pneumoniae (ATCC 10031), and Streptococcus pneumoniae (ATCC 6305). The microdilution method was used for determination of the minimum inhibitory concentration (MIC) during evaluation of the antibacterial activity. The methylene chloride extract showed no activity against the selected microorganisms. Ursolic acid was active against B. cereus, showing a MIC value of 20 mu g/mL. Oleanolic acid was effective against B. cereus and S. pneumoniae with a MIC of 80 mu g/mL in both cases. The mixture of triterpenes, ursolic and oleanolic acids, did not enhance the antimicrobial activity. However, the acetyl and methyl ester derivatives, prepared from ursolic acid, increased the inhibitory activity for S. pneumoniae. (AU)

FAPESP's process: 09/00604-8 - Molecules of interest: isolation, identification,structural modifications and evaluation by several biological assays
Grantee:Wilson Roberto Cunha
Support Opportunities: Regular Research Grants