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(Reference retrieved automatically from Google Scholar through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Cavum septum pellucidum and adhesio interthalamica in schizophrenia: an MRI study

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Author(s):
Crippa‚ J.A.S. ; Zuardi‚ A.W. ; Busatto‚ G.F. ; Sanches‚ R.F. ; Santos‚ A.C. ; Araújo‚ D. ; Amaro‚ E. ; Hallak‚ J.E.C. ; Ng‚ V. ; McGuire‚ P.K.
Total Authors: 10
Document type: Journal article
Source: EUROPEAN PSYCHIATRY; v. 21, n. 5, p. 291-299, 2006.
Abstract

Several studies have independently suggested that patients with schizophrenia are more likely to have an enlarged cavum septum pellucidum (CSP) and an absent adhesio interthalamica (AI), respectively. However, neither finding has been consistently replicated and it is unclear whether there is an association between these two midline brain abnormalities. Thus, we compared the prevalence of absent AI and the prevalence, size and volume of CSP in 38 patients with schizophrenia and 38 healthy controls using magnetic resonance imaging (MRI). There were no between group differences in the presence or volume of CSP; however, an enlarged CSP was commoner among patients than controls. There was also a positive correlation between CSP ratings and volumes. No differences in the presence or absence of the AI were found between patients and controls; however, an absent AI was commoner in male patients with schizophrenia than females. There was absolutely no overlap between the presence of a large CSP and an absence of AI. In conclusion, our findings are in line with several case series and other MRI investigations that have shown a higher incidence of putatively developmental brain abnormalities in patients with schizophrenia, particularly in males, and support the neurodevelopmental model of this disorder. (c) 2005 Elsevier SAS. All rights reserved. (AU)

FAPESP's process: 98/10639-7 - Neurobiology of Behavioral responses to aversive events
Grantee:Francisco Silveira Guimaraes
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 99/12205-7 - Obsessive-Compulsive Disorder: pathogenesis and treatment
Grantee:Eurípedes Constantino Miguel Filho
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 02/13197-2 - Participation of glutamate and nitric oxide on the pathophysiology of neuropsychiatry disorders
Grantee:Francisco Silveira Guimaraes
Support Opportunities: Research Projects - Thematic Grants