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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Ingenamine G and cyclostellettamines G-I, K, and L from the new Brazilian species of marine sponge Pachychalina sp

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Oliveira, Jaine H. H. L. de ; Grube, Achim ; Kock, Matthias ; Berlinck, Roberto Gomes de Souza [4] ; Macedo, Mario L. ; Ferreira, Antonio G. ; Hajdu, Eduardo
Total Authors: 7
Document type: Journal article
Source: Journal of Natural Products; v. 67, n. 10, p. 1685-1689, Oct. 2004.
Field of knowledge: Physical Sciences and Mathematics - Chemistry

The chemical investigation of the cytotoxic and antituberculosis active MeOH crude extract of the marine sponge Pachychalina sp. led to the isolation of six new nitrogenous metabolites, including ingenamine G (1), as well as a mixture of new cyclostellettamines G, H, I, K, and L (10-14) with the known cyclostellettamines A-F (4-9). Structural assignments of compound 1 were based on the analysis of MS and NMR data, while the structures of compounds 10-14 could be established by HPLC-MS/MS analysis. Ingenamine G displayed cytotoxic activity against HCT-8 (colon), B16 (leukemia), and MCF-7 (breast) cancer cell lines, antibacterial activity against Staphylococcus aureus (ATCC 25923), Escherichia coli (ATCC 25922), and four oxacilin-resistant S. aureus strains, and antimycobacterial activity against Mycobacterium tuberculosis H37Rv. (AU)

FAPESP's process: 01/03095-5 - Natural products from marine invertebrates: potential chemotherapic anti-proliferative, antibiotic and against tropical diseases agents
Grantee:Roberto Gomes de Souza Berlinck
Support type: Research Projects - Thematic Grants