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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Coronary plaque rupture in patients with myocardial infarction after noncardiac surgery: Frequent and dangerous

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Gualandro, Danielle Menosi [1] ; Campos, Carlos Augusto [2] ; Calderaro, Daniela [1] ; Yu, Pai Ching [1] ; Marques, Andre Coelho [1] ; Pastana, Adriana Feio [1] ; Lemos, Pedro Alves [2] ; Caramelli, Bruno [1]
Total Authors: 8
[1] Univ Sao Paulo, Sch Med, Interdisciplinary Med Cardiol Unit, Heart Inst InCor, BR-05508 Sao Paulo - Brazil
[2] Univ Sao Paulo, Sch Med, Intervent Cardiol Unit, Heart Inst InCor, BR-05508 Sao Paulo - Brazil
Total Affiliations: 2
Document type: Journal article
Source: ATHEROSCLEROSIS; v. 222, n. 1, p. 191-195, MAY 2012.
Web of Science Citations: 66

Purpose: The pathophysiology of acute coronary syndromes (ACS) after noncardiac surgery is not established yet. Thrombosis over a vulnerable plaque or decreased oxygen supply secondary to anemia or hypotension may be involved. The purpose of this study was to investigate the pathophysiology of ACS complicating noncardiac surgery. Methods: Clinical and angiographic data were prospectively recorded into a database for 120 consecutive patients that had an ACS after noncardiac surgery (PACS), for 120 patients with spontaneous ACS (SACS), and 240 patients with stable coronary artery disease (CAD). Coronary lesions with obstructions greater than 50% were classified based on two criteria: Ambrose's classification and complex morphology. The presence of Ambrose's type II or complex lesions were compared between the three groups. Results: We analyzed 1470 lesions in 480 patients. In PACS group, 45% of patients had Ambrose's type II lesions vs. 56.7% in SACS group and 16.4% in stable CAD group (P < 0.001). Both PACS and SACS patients had more complex lesions than patients in stable CAD group (56.7% vs. 79.2% vs. 31.8%, respectively; P < 0.001). Overall, the independent predictors of plaque rupture were being in the group PACS (P < 0.001, OR 2.86; CI, 1.82-4.52 for complex lesions and P < 0.001, OR 3.43; CI, 2.1-5.6 for Ambrose's type II lesions) or SACS (P < 0.001, OR 8.71; CI, 5.15-14.73 for complex lesions and P < 0.001, OR 5.99; CI, 3.66-9.81 for Ambrose's type II lesions). Conclusions: Nearly 50% of patients with perioperative ACS have evidence of coronary plaque rupture, characterizing a type 1 myocardial infarction. (C) 2012 Elsevier Ireland Ltd. All rights reserved. (AU)

FAPESP's process: 09/05859-4 - Acute coronary syndromes complicating noncardiac surgery: angiographic findings and comparison with spontaneous events
Grantee:Bruno Caramelli
Support Opportunities: Regular Research Grants