Paradoxical sleep deprivation induces muscle atrophy

Author(s)

Dattilo, Murilo ^{[1, 2]} ; Moreira Antunes, Hanna Karen ^{[2, 3]} ; Medeiros, Alessandra ^[3] ; Monico-neto, Marcos ^[2] ; Souza, Helton de S. A. ^[2] ; Lee, Kil Sun ^[4] ; Tufik, Sergio ^[1] ; de Mello, Marco Tulio ^{[1, 2]}

Affiliation

^[1] Univ Fed Sao Paulo, Dept Psicobiol, BR-04020050 Sao Paulo - Brazil

^[2] CEPE, Sao Paulo - Brazil

^[3] Univ Fed Sao Paulo, Dept Biociencias, Santos - Brazil

^[4] Univ Fed Sao Paulo, Dept Bioquim, BR-04020050 Sao Paulo - Brazil

• Document type: Journal article
• Source: MUSCLE & NERVE; v. 45, n. 3, p. 431-433, MAR 2012.
• Web of Science Citations: 21

Abstract

Introduction: Because paradoxical sleep deprivation (PSD) induces a catabolic hormone profile, we sought to evaluate the morphology of the tibialis anterior (TA) muscle and testosterone and corticosterone levels of paradoxical sleepdeprived rats.Methods: Three study groups of rats were established: the first group was sleep deprived for 96 h; the second group was also sleep deprived for 96 h, but then returned to their home-cage and allowed to sleep for the next 96 h; and the third group was the control group, with a normal sleep cycle. Results: PSD reduced the weight and fiber cross-sectional area of the TA muscle. Moreover, PSD enhanced plasma corticosterone and reduced serum testosterone levels. The 96 h of sleep after PSD was sufficient to restore partially the morphology of TA, while hormones returned to basal levels. Conclusion: PSD induces hormonal alterations that may mediate muscle atrophy. Muscle Nerve, 2012 (AU)

• FAPESP's process: 09/11056-1 - Effects of sleep deprivation in muscle recovery
• Grantee: Murilo Dattilo
• Support Opportunities: Scholarships in Brazil - Master
• FAPESP's process: 98/14303-3 - Center for Sleep Studies
• Grantee: Sergio Tufik
• Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC