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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Differential MiRNA expression in childhood acute lymphoblastic leukemia and association with clinical and biological features

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Author(s):
de Oliveira, Jaqueline Carvalho [1] ; Scrideli, Carlos Alberto [2] ; Brassesco, Maria Sol [2] ; Morales, Andressa Gois [1] ; Pezuk, Julia Alejandra [1] ; Queiroz, Rosane de Paula [2] ; Yunes, Jose Andres [3, 4] ; Brandalise, Silvia Regina [3, 4] ; Tone, Luiz Gonzaga [2, 1]
Total Authors: 9
Affiliation:
[1] Univ Sao Paulo, Dept Genet, BR-14049900 Sao Paulo - Brazil
[2] Univ Sao Paulo, Dept Paediat, BR-14049900 Sao Paulo - Brazil
[3] Ctr Infantil Boldrini, Sao Paulo - Brazil
[4] Univ Campinas UNICAMP, Dept Paediat, Sao Paulo - Brazil
Total Affiliations: 4
Document type: Journal article
Source: Leukemia Research; v. 36, n. 3, p. 293-298, MAR 2012.
Web of Science Citations: 39
Abstract

The present study aimed to analyze the expression profile of the microRNAs previously described as associated with childhood ALL, miR-92a, miR-100, miR-125a-5p, miR-128a, miR-181b, miR-196b and let-7e, and their association with biological/prognostic features in 128 consecutive samples of childhood acute lymphoblastic leukemia (ALL) by quantitative real-time PCR. A significant association was observed between higher expression levels of miR-196b and T-ALL, miR-100 and patients with low white blood cell count at diagnosis and t(12;21) positive ALL. These findings suggest a potential activity of these microRNAs in pediatric ALL biology. (C) 2011 Elsevier Ltd. All rights reserved. (AU)

FAPESP's process: 09/10191-2 - Influence of microRNAs in acute lymphoblastic leukemia
Grantee:Jaqueline Carvalho de Oliveira
Support type: Scholarships in Brazil - Doctorate