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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Focal adhesion kinase - The basis of local hypertrophic signaling domains

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Author(s):
Franchini, K. G. [1, 2]
Total Authors: 1
Affiliation:
[1] Univ Estadual Campinas, Sch Med, Dept Internal Med, Campinas, SP - Brazil
[2] Assoc Brasileira Luz Sincrotron, Lab Nacl Biociencias, BR-13084971 Campinas, SP - Brazil
Total Affiliations: 2
Document type: Review article
Source: JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY; v. 52, n. 2, SI, p. 485-492, FEB 2012.
Web of Science Citations: 29
Abstract

Focal adhesion kinase (FAK), a broadly expressed non-receptor tyrosine kinase which transduces signals from integrins, growth and hormonal factors, is a key player in many fundamental biological processes and functions, including cell adhesion, migration, proliferation and survival. The involvement of FAK in this range of functions supports its role in important aspects of organismal development and disease, such as central nervous system and cardiovascular development, cancer, cardiac hypertrophy and tissue fibrosis. Many functions of FAK are correlated with its tyrosine kinase activity, which is temporally and spatially controlled by complex intra-molecular autoinhibitory conformation and inter-molecular interactions with protein and lipid partners. The inactivation of FAK in mice results in embryonic lethality attributed to the lack of proper development and function of the heart. Accordingly, embryonic FAK myocyte-specific knockout mice display lethal cardiac defects such as thin ventricle wall and ventricular septum defects. Emerging data also support a role for FAK in the reactive hypertrophy and failure of adult hearts. Moreover, the mechanisms that regulate FAK in differentiated cardiac myocytes to biomechanical stress and soluble factors are beginning to be revealed and are discussed here together with data that connect FAK to its downstream effectors. This article is part of a Special Issue entitled ``Local Signaling in Myocytes{''}. (C) 2011 Elsevier Ltd. All rights reserved. (AU)

FAPESP's process: 08/57629-0 - New 2,8-disubstituted quinazolines with potential inhibitory activity of focal adhesion kinase (FAK)
Grantee:João Eustáquio Antunes
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 06/54878-3 - Pathogenesis of cardiac hypertrophy and failure: mechanisms activated by mechanical stress
Grantee:Kleber Gomes Franchini
Support type: Research Projects - Thematic Grants