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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Seizures in Primary Antiphospholipid Syndrome: The Relevance of Smoking to Stroke

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Author(s):
de Carvalho, Jozelio Freire [1] ; Pasoto, Sandra Gofinet [1] ; Appenzeller, Simone [2]
Total Authors: 3
Affiliation:
[1] Univ Sao Paulo, Div Rheumatol, Fac Med, Hosp Clin, BR-01246903 Sao Paulo - Brazil
[2] Univ Estadual Campinas, Div Rheumatol, Fac Med, Hosp Clin, Campinas, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: CLINICAL & DEVELOPMENTAL IMMUNOLOGY; 2012.
Web of Science Citations: 11
Abstract

Objectives. To evaluate the frequency of seizures in primary antiphospholipid syndrome (PAPS) and their possible clinical and laboratory associations. Methods. Eighty-eight PAPS patients (Sydney's criteria) were analyzed by a standard interview, physical examination and review of medical charts. Risk factors for seizures, clinical manifestations, associated comorbidities, and antiphospholipid antibodies were evaluated. Results. Nine (10.2%) patients with seizures were identified, 77.8% had convulsions onset after PAPS diagnosis. Mean age, gender, and race were comparable in groups with or without seizures. Interestingly, a higher frequency of current smoking (44.4 versus 10.1%, P = 0.019) was observed in the first group. Stroke, Sneddon's syndrome, and livedo reticularis were more frequent in PAPS patients with seizures than those without seizures, although not statistically significant (P > 0.05). Comparison between patients with seizures onset after PAPS diagnosis (n = 7) and those without convulsions (n = 79) demonstrated a higher frequency of current smoking (42.9 versus 10%, P = 0.042) and stroke in the first group (71.4 versus 30.4%, P = 0.041). Regression analysis confirmed that smoking (P = 0.030) and stroke (P = 0.042) were independently associated to seizures. Conclusion. About 10.2% of PAPS patients had convulsions, predominantly after PAPS diagnosis, and seizures were associated to current smoking and stroke. (AU)

FAPESP's process: 09/06049-6 - Blood and cerebrospinal fluid biomarkers associated with structural and functional central nervous system abnormalities in Systemic lupus erythematosus
Grantee:Simone Appenzeller
Support type: Scholarships in Brazil - Young Researchers
FAPESP's process: 10/10013-4 - Serum autoantibodies in primary Sjögren's syndrome: study of clinical associations and possible correlations with antibodies to viral antigens (EBV and HTLV-1)
Grantee:Sandra Gofinet Pasoto
Support type: Regular Research Grants
FAPESP's process: 08/02917-0 - Blood and cerebrospinal fluid biomarkers associated with structural and functional central nervous system abnormalities in systemic lupus erythematosus
Grantee:Simone Appenzeller
Support type: Research Grants - Young Investigators Grants