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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Osteosarcoma arising from osteochondroma of the tibia: case report and cytogenetic findings

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Author(s):
Engel, E. E. [1] ; Nogueira-Barbosa, M. H. [2] ; Brassesco, M. S. [3] ; Silva, G. E. B. [4] ; Valera, E. T. [3] ; Peria, F. M. [5] ; Motta, T. C. [5] ; Tone, L. G. [3]
Total Authors: 8
Affiliation:
[1] Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Biomecan Med & Reabilitacao Aparelho Locomot, Ribeirao Preto, SP - Brazil
[2] Univ Sao Paulo, Fac Med Ribeirao Preto, Div Diagnost Imagem, Dept Med Interna, Ribeirao Preto, SP - Brazil
[3] Univ Sao Paulo, Fac Med Ribeirao Preto, Div Oncol Pediat, Dept Puericultura & Pediat, Ribeirao Preto, SP - Brazil
[4] Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Patol, Ribeirao Preto, SP - Brazil
[5] Univ Sao Paulo, Fac Med Ribeirao Preto, Div Oncol, Dept Med Interna, Ribeirao Preto, SP - Brazil
Total Affiliations: 5
Document type: Journal article
Source: Genetics and Molecular Research; v. 11, n. 1, p. 448-454, 2012.
Web of Science Citations: 5
Abstract

Osteochondroma is a cartilage capped benign tumor developing mainly at the juxta-epiphyseal region of long bones. The rate of malignant transformation, mainly into chondrosarcoma, is estimated to be less than 1-3%. Transformation into osteosarcoma is very rare and has been reported only thirteen times. There is little information on treatment and outcome. We report the case of a secondary osteosarcoma arising in the left tibia of a 23-year-old male, 10 years after the initial diagnosis of osteochondroma and after two partial resections. Malignant transformation occurred at the stalk and not at the cartilage cap, as would normally be expected. Chromosome banding analysis revealed the karyotype: 46,XY, t(3;13)(q21;q34) {[}2]/46,XY {[}18]. Records from additional cases will help determine the parameters that define these rare secondary bone lesions. (AU)