| Full text | |
| Author(s): |
Uribe-Marino, Andres
[1, 2]
;
Francisco, Audrey
[2]
;
Castiblanco-Urbina, Maria Angelica
[1, 2]
;
Twardowschy, Andre
[2]
;
Salgado-Rohner, Carlos Jose
[2]
;
Crippa, Jose Alexandre S.
[3, 4]
;
Cecilio Hallak, Jaime Eduardo
[3, 4]
;
Zuardi, Antonio Waldo
[3]
;
Coimbra, Norberto Cysne
[1, 2]
Total Authors: 9
|
| Affiliation: | [1] Inst Neurosci & Behav INeC, Ribeirao Preto, SP - Brazil
[2] Univ Sao Paulo, Lab Neuroanat & Neuropsicobiol, Dept Farmacol, Fac Med Ribeirao Preto, BR-14049900 Ribeirao Preto, SP - Brazil
[3] Univ Sao Paulo, Dept Neurociencias & Ciencias Comportamento, Setor Psiquiatria, Fac Med Ribeirao Preto, BR-14049900 Ribeirao Preto, SP - Brazil
[4] Univ Fed Rio Grande do Sul, Natl Inst Sci & Translat Technol Med INCT TM, CNPq, BR-90046900 Porto Alegre, RS - Brazil
Total Affiliations: 4
|
| Document type: | Journal article |
| Source: | NEUROPSYCHOPHARMACOLOGY; v. 37, n. 2, p. 412-421, JAN 2012. |
| Web of Science Citations: | 42 |
| Abstract | |
Several pharmacological targets have been proposed as modulators of panic-like reactions. However, interest should be given to other potential therapeutic neurochemical agents. Recent attention has been given to the potential anxiolytic properties of cannabidiol, because of its complex actions on the endocannabinoid system together with its effects on other neurotransmitter systems. The aim of this study was to investigate the effects of cannabidiol on innate fear-related behaviors evoked by a prey vs predator paradigm. Male Swiss mice were submitted to habituation in an arena containing a burrow and subsequently pre-treated with intraperitoneal administrations of vehicle or cannabidiol. A constrictor snake was placed inside the arena, and defensive and non-defensive behaviors were recorded. Cannabidiol caused a clear anti-aversive effect, decreasing explosive escape and defensive immobility behaviors outside and inside the burrow. These results show that cannabidiol modulates defensive behaviors evoked by the presence of threatening stimuli, even in a potentially safe environment following a fear response, suggesting a panicolytic effect. Neuropsychopharmacology (2012) 37, 412-421; doi:10.1038/npp.2011.188; published online 14 September 2011 (AU) | |
| FAPESP's process: | 09/01153-0 - Involvement of locus coeruleus neural pathways and noradrenergic neurotransmission in the dorsal raphe nucleus in antinociceptive processes induced by oriented escape reactions evoked by chemical stimulation of the medial hypothalamus |
| Grantee: | Andres Uribe Marino |
| Support Opportunities: | Scholarships in Brazil - Master |
| FAPESP's process: | 08/08955-1 - Involvement of the Dorsal Raphe Nucleus Neural Networks and Serotonergic Neurotransmittion in the Locus Coeruleus in Antinociceptive Processess Induced by Oriented Escape Reaction Evoked by Chemical Stimulation of the Medial Hypothalamus. |
| Grantee: | Audrey Franceschi Biagioni |
| Support Opportunities: | Scholarships in Brazil - Master |
| FAPESP's process: | 08/00531-8 - Study of the interaction between Opioid and GABAergic mechanisms in the Dorsal Mesencephalon and its Role in the Modulation of Defensive Behaviour Organized in the Inferior Colliculus and Periaqueductal Grey Matter |
| Grantee: | Andre Twardowschy |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 09/01157-5 - Study of the involvement of the opioid system and the neural networks between medial hypothalamus and periaqueductal grey matter in antinociceptive processes induced by oriented escaped reactions evoked after chemical stimulation of the medial hypothalamus |
| Grantee: | Maria Angelica Castiblanco Urbina |
| Support Opportunities: | Scholarships in Brazil - Master |