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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Hepatitis delta in HIV/HBV co-infected patients in Brazil: is it important?

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Mendes-Correa, Maria Cassia [1, 2] ; Gomes-Gouvea, Michele S. [3, 4] ; Alvarado-Mora, Monica V. [3, 4] ; Da Silva, Mariliza H. [5] ; Lazari, Carolina [1] ; Cavalcanti, Norma C. S. [1] ; Alonso, Flaviane K. [2] ; Carpinelli, Catia C. [2] ; Uip, David E. [2] ; Pinho, Joao R. R. [3, 4]
Total Authors: 10
[1] Univ Sao Paulo, Sch Med, Dept Infect Dis, BR-05403000 Sao Paulo - Brazil
[2] ABC Med Sch, Infect Dis Res Unit, Santo Andre - Brazil
[3] Univ Sao Paulo, Sch Med, Dept Gastroenterol, BR-05403000 Sao Paulo - Brazil
[4] Univ Sao Paulo, Sch Med, Inst Trop Med, BR-05403000 Sao Paulo - Brazil
[5] AIDS Outpatient Clin, Sao Paulo - Brazil
Total Affiliations: 5
Document type: Journal article
Web of Science Citations: 15

Objectives: This study was carried out to evaluate the prevalence of hepatitis delta virus (HDV) among human immunodeficiency virus (HIV)/hepatitis B virus (HBV) co-infected patients from Sao Paulo, in the Southeast Region of Brazil. Methods: A total of 3259 HIV patients with serological markers for HBV were initially enrolled in the study. Among these patients, 154 (4.7%) were hepatitis B surface antigen (HBsAg)-reactive. Serum samples were obtained from 86 HBsAg-positive patients and were submitted to anti-HDV serological assay. Results: One (1.2%) HIV/HBV patient was found to be anti-HDV-positive, and the HDV infection was confirmed by PCR. Phylogenetic analysis showed that this HDV sequence grouped with other HDV genotype 1 sequences from Mediterranean European countries, suggesting that this virus has a common ancestor with HDV from that region. This patient was probably infected by sexual transmission, as he reported unprotected sexual intercourse with multiple partners over the course of many years but denied intravenous drug use or any travel to the Brazilian Amazon, an area known to have a high HDV prevalence. Conclusions: HDV infection is infrequent in the Southeast Region of Brazil, however there have been a few cases in this region. HIV/HBV patients are at potential risk for HDV infection, therefore investigations for the presence of HDV infection must be carried out in these patients. (C) 2011 International Society for Infectious Diseases. Published by Elsevier Ltd. All rights reserved. (AU)

FAPESP's process: 10/50081-9 - Prevalence of primary resistance to antiviral therapy against hepatitis B in patients with chronic hepatitis B virus infection and not submitted to treatment
Grantee:Michele Soares Gomes Gouvêa
Support Opportunities: Scholarships in Brazil - Doctorate