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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Paternal treatment with cisplatin impairs reproduction of adult male offspring in rats

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Alves Favareto, Ana Paula [1] ; de Toledo, Fabiola Choqueta [2] ; Kempinas, Wilma De Grava [2]
Total Authors: 3
[1] State Univ Campinas UNICAMP, Program Cellular & Struct Biol, Campinas, SP - Brazil
[2] Univ Estadual Paulista, UNESP, Inst Biociencias, Dept Morfol, BR-18618970 Botucatu, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: REPRODUCTIVE TOXICOLOGY; v. 32, n. 4, p. 425-433, DEC 2011.
Web of Science Citations: 14

This study evaluated the acute and persistent effects of paternal cisplatin-treatment on progeny. Wistar male rats (45 days old) were assigned into 2 groups. Control and cisplatin (CP: 1 mg/kg-d, 5 days/week, for 3 weeks, ip.). Male rats at 66 (end of treatment, acute effects evaluation) and 140 days old (after recovery period, persistent effects evaluation) were mated with females. Fetal and post-natal developments of the offspring sired by treated-male mated in both ages were evaluated, including fertility of adult male offspring. No adverse effects in fetal development or puberty onset were seen in CP offspring. However, testicular descent was delayed and postnatal growth was impaired in these animals (acute effect). Moreover, seminal vesicle weight and epididymal sperm count from adult progeny were affected (acute effects) by paternal CP-exposure. The only persistent effect found was alterations in the spermatogenesis. We conclude that paternal CP-administration during pen-puberty affects reproductive endpoints of the progeny. (C) 2011 Elsevier Inc. All rights reserved. (AU)