Advanced search
Start date
Betweenand
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Cytogenetic Instability in Childhood Acute Lymphoblastic Leukemia Survivors

Full text
Author(s):
Brassesco, Maria Sol [1, 2] ; Xavier, Danilo Jordao [1] ; Camparoto, Marjori Leiva [1] ; Montaldi, Ana Paula [1] ; D'Auria Vieira de Godoy, Paulo Roberto [1] ; Scrideli, Carlos Alberto [2] ; Tone, Luiz Gonzaga [2] ; Sakamoto-Hojo, Elza Tiemi [1, 3]
Total Authors: 8
Affiliation:
[1] Univ Sao Paulo, Dept Genet, Fac Med Ribeirao Preto, BR-14040901 Sao Paulo - Brazil
[2] Univ Sao Paulo, Dept Puericultura & Pediatria, Fac Med Ribeirao Preto, BR-14040901 Sao Paulo - Brazil
[3] Univ Sao Paulo, Dept Biol, Fac Filosofia Ciencias & Letras Ribeirato Preto F, BR-14040901 Sao Paulo - Brazil
Total Affiliations: 3
Document type: Journal article
Source: JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY; 2011.
Web of Science Citations: 5
Abstract

Contemporary anticancer therapies have largely improved the outcome for children with cancer, especially for Acute Lymphoblastic Leukemia (ALL). Actually, between 78% and 85% of patients achieve complete remission and are alive after 5 years of therapy completion. However, as cure rates increase, new concerns about the late effects of genotoxic treatment emerge, being the risk of developing secondary neoplasias, the most serious life-threatening rising problem. In the present paper, we describe and review the cytogenetic findings in peripheral lymphocytes from ALL survivors, and discuss aspects associated to the occurrence of increased chromosome rearrangements in this growing cohort. (AU)