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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Antigenotoxicity of artepillin C in vivo evaluated by the micronucleus and comet assays

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Author(s):
Bentes Monteiro Neto, Moacir de Azevedo [1] ; de Souza Lima, Ildercilio Mota [1] ; Furtado, Ricardo Andrade [2] ; Bastos, Jairo Kenupp [2] ; da Silva Filho, Ademar Alves [3] ; Tavares, Denise Crispim [1]
Total Authors: 6
Affiliation:
[1] Univ Franca, BR-14404600 Sao Paulo - Brazil
[2] Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, BR-14040903 Sao Paulo - Brazil
[3] Univ Fed Juiz Fora, Dept Farmaceut, Fac Farm, BR-36035900 Juiz De Fora, MG - Brazil
Total Affiliations: 3
Document type: Journal article
Source: JOURNAL OF APPLIED TOXICOLOGY; v. 31, n. 8, p. 714-719, NOV 2011.
Web of Science Citations: 8
Abstract

Artepillin C (3,5-diprenyl-p-coumaric acid), a major compound found in Brazilian green propolis and Baccharis dracunculifolia, shows anti-inflammatory, antibacterial, antiviral, antioxidant and antitumoral activities, among others. The aim of this study was to evaluate the genotoxic potential of artepillin C and its ability to prevent the chemically induced chromosome breakage or loss and the primary DNA damage using the micronucleus and comet assays in male Swiss mice, respectively. The animals were treated by gavage with different doses of artepillin C (0.4, 0.8 and 1.6 kg(-1) b.w.). For the antigenotoxicity assays, the different doses of artepillin C were administered simultaneously to doxorubicin (DXR; micronucleus test; 15 mg kg(-1) b.w.) and to methyl methanesulfonate (MMS; comet assay; 40 mg kg(-1) b.w.). The results showed that artepillin C itself was not genotoxic in the mouse micronucleus and comet assays. In the animals treated with artepillin C and DXR, the number of micronucleated reticulocytes was significantly lower in comparison with the animals treated only with DXR. Regarding antigenotoxicity, artepillin C at the tested doses significantly reduced the extent of DNA damage in liver cells induced by MMS. Copyright (C) 2011 John Wiley \& Sons, Ltd. (AU)

FAPESP's process: 07/07211-6 - Study of mutagenic and/or antimutagenic activity of Baccharis dracunculifolia and Artepillin C in mammalian cells
Grantee:Denise Crispim Tavares Barbosa
Support type: Regular Research Grants
FAPESP's process: 09/05944-1 - In vivo evaluation of mutagenic/genotoxic and antimutagenic/antigenotoxic potential of artepillin C
Grantee:Ildercílio Mota de Souza Lima
Support type: Scholarships in Brazil - Scientific Initiation