Influence of Maternal Hyperglycemia on IL-10 and TNF-alpha Production: The Relationship with Perinatal Outcomes

Author(s)

Moreli, Jusciele Brogin ^[1] ; Morceli, Glilciane ^[1] ; De Luca, Ana Karina C. ^[2] ; Magalhaes, Claudia G. ^[2] ; Costa, Roberto A. A. ^[2] ; Damasceno, Debora Cristina ^{[2, 1]} ; Cunha Rudge, Marilza Vieira ^{[2, 1]} ; Paranhos Calderon, Iracema Mattos ^{[2, 1]}

Affiliation

^[1] UNESP Sao Paulo State Univ, Postgrad Program Gynecol Obstet & Mastol, Botucatu Med Sch, Botucatu, SP - Brazil

^[2] UNESP Sao Paulo State Univ, Dept Obstet & Gynecol, Botucatu Med Sch, BR-18618000 Sao Paulo - Brazil

• Document type: Journal article
• Source: JOURNAL OF CLINICAL IMMUNOLOGY; v. 32, n. 3, p. 604-610, JUN 2012.
• Web of Science Citations: 17

Abstract

Aims This study was conducted to evaluate maternal and placental concentrations of interleukin 10 (IL-10) and tumor necrosis factor-alpha (TNF-alpha) in pregnant women with glycemic mean (GM) < or >= 100 mg/dL, as well as correlate IL-10 and TNF-alpha placental concentrations with perinatal outcomes. Methods One hundred eighty-six pregnant women were distributed in groups determined by a GM < 100 mg/dL or a GM >= 100 mg/dL. The GM, HbA1c levels, maternal and placental concentrations of IL-10 and TNF-alpha, and the correlation of placental cytokines with perinatal outcomes were evaluated. Results In maternal blood, the lowest concentrations of IL-10 (p=00.0019) and TNF-alpha (p=0.0185) were observed in the GM >= 100-mg/dL group. The placentas from GM >= 100 mg/dL group exhibited higher TNF-alpha concentrations (p=0.0385). Placental IL-10 directly correlated with hemoglobin (r=0.63; p=0.02) and insulin (r=0.78; p=0.01) levels in the umbilical cord and with 1-min (r=0.53; p=0.0095) and 5-min (r=0.69; p=0.0003) Apgar scores. Placental TNF-alpha displayed a tendency to inversely correlate with fetal weight (r=-0.41; p=0.05). Conclusion Compared to GM<100 mg/dL, GM >= 100 mg/dL was associated with a reduction in maternal IL-10 and TNF-alpha concentrations and increased placental TNF-alpha production. Placental IL-10 production was similar in both groups studied and directly correlated with hemoglobin and umbilical cord insulin levels, as well as with the 1- and 5-min Apgar scores. (AU)

• FAPESP's process: 09/03253-1 - IL-10 and TNF alpha in the maternal blood and placentas of gestations complicated by diabetes or mild hyperglycemia - correlation with glycemic control and perinatal outcomes.
• Grantee: Jusciele Brogin Moreli
• Support Opportunities: Scholarships in Brazil - Master