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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Genetic association study of polymorphisms FOXP3 and FCRL3 in women with endometriosis

Full text
Author(s):
Barbosa, Caio P. [1] ; Teles, Juliana S. [1] ; Lerner, Tatiana G. [1] ; Peluso, Carla [1] ; Mafra, Fernanda A. [1] ; Vilarino, Fabia L. [1] ; Christofolini, Denise M. [1] ; Bianco, Bianca [1]
Total Authors: 8
Affiliation:
[1] Fac Med Santo Andre Sao Bernardo do Campo & Sao C, Dept Gynecol & Obstet, Human Reprod & Genet Ctr, Santo Andre - Brazil
Total Affiliations: 1
Document type: Journal article
Source: Fertility and Sterility; v. 97, n. 5, p. 1124-1128, MAY 2012.
Web of Science Citations: 12
Abstract

Objective: To consider a possible cumulative effect of two genetic polymorphisms (FOXP3 C-2383T/rs3761549 and FCRL3 C-169T/rs7528684) that were previously shown to be associated with endometriosis. Design: Genetic association study. Setting: Human reproduction outpatient clinic of Faculdade de Medicina do ABC. Patient(s): One hundred eighty-eight infertile women with endometriosis and 169 controls. Intervention(s): Detection of polymorphisms FOXP3 (C-2383T/rs3761549) and FCRL3 (C-169T/rs7528684) by TaqMan real-time polymerase chain reaction. The results were analyzed statistically. Main Outcome Measure(s): Genotype distribution, allele frequency, and combination analysis of the FOXP3 and FCRL3 polymorphisms. Result(s): Single-marker analysis revealed a significant association of FOXP3 C-2383T and FCRL3 C-169T, independently, with endometriosis-related infertility, regardless of the stage of the disease. Considering the combined genotypes of FCRL3 and FOXP3 polymorphisms, a positive association was found between genotypes FCRL3TT/FOXP3CT, FCRL3CT/FOXP3CT, and FCRL3CC/FOXP3CT and the risk of endometriosis development. Moreover, a progression of the disease risk was observed according to the presence of one or two copies of risk allele FCRL3 C and only one copy of risk allele FOXP3 T (odds ratio {[}OR] = 2.14, OR = 3.25, and OR = 6.0, respectively, for genotypes FCRL3TT/FOXP3CT, FCRL3CT/FOXP3CT, and FCRL3CC/FOXP3CT). Conclusion(s): Our findings support a possible gene-gene interaction leading to a cumulative effect on endometriosis development. (Fertil Steril (R) 2012; 97: 1124-8. (C) 2012 by American Society for Reproductive Medicine.) (AU)

FAPESP's process: 09/09980-2 - Study of PTPN22 polymorphism in women with endometriosis
Grantee:Caio Parente Barbosa
Support Opportunities: Regular Research Grants
FAPESP's process: 10/01104-6 - Study of Fok1 polymorphism of VDR gene in women with endometriosis
Grantee:Tatiana Goberstein Lerner
Support Opportunities: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 09/11298-5 - TELOMERASE EXPRESSION IN ENDOMETRIOSIS
Grantee:Fernanda Abani Mafra
Support Opportunities: Scholarships in Brazil - Master