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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

MicroRNA expression and activity in pediatric acute lymphoblastic leukemia (ALL)

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de Oliveira, Jaqueline C. [1] ; Brassesco, Maria Sol [2] ; Scrideli, Carlos Alberto [2] ; Tone, Luiz Gonzaga [2] ; Narendran, Aru [3]
Total Authors: 5
[1] Univ Sao Paulo, Sch Med Ribeirao Preto, Dept Genet, BR-14048900 Ribeirao Preto, SP - Brazil
[2] Univ Sao Paulo, Sch Med Ribeirao Preto, Dept Pediat, BR-14048900 Ribeirao Preto, SP - Brazil
[3] Alberta Childrens Prov Gen Hosp, Div Pediat Oncol, Calgary, AB T2T 5C7 - Canada
Total Affiliations: 3
Document type: Review article
Source: PEDIATRIC BLOOD & CANCER; v. 59, n. 4, p. 599-604, OCT 2012.
Web of Science Citations: 25

Acute lymphoblastic leukemia (ALL) is the most common type of pediatric neoplasia. Highly heterogeneous, ALL includes several genetic subtypes with varying clinical outcome. Although, some features are well established as prognostic predictors, the details of the molecular mechanisms underlying different phenotypes are only beginning to emerge. Recently, microRNAs (miRNAs) have been shown to influence a range of physiological processes and, consequently, alterations in their expression and functions have been associated with the development of many cancers, including leukemia. This article aims to review the current state of knowledge of the role of miRNAs on the biology of childhood ALL, also including relevant findings from the adult leukemia literature. Pediatr Blood Cancer 2012;59:599604. (c) 2012 Wiley Periodicals, Inc. (AU)

FAPESP's process: 09/10191-2 - Influence of MicroRNAs in Acute Lymphoblastic Leukemia
Grantee:Jaqueline Carvalho de Oliveira
Support Opportunities: Scholarships in Brazil - Doctorate