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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Organocatalytic asymmetric epoxidation and tandem epoxidation/Passerini reaction under eco-friendly reaction conditions

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Author(s):
Deobald, Anna Maria [1] ; Correa, Arlene G. [1] ; Rivera, Daniel G. [2] ; Paixao, Marcio Weber [1]
Total Authors: 4
Affiliation:
[1] Univ Fed Sao Carlos, Dept Quim, BR-13565905 Sao Carlos, SP - Brazil
[2] Univ Havana, Fac Chem, Ctr Nat Prod Study, Havana 10400 - Cuba
Total Affiliations: 2
Document type: Journal article
Source: ORGANIC & BIOMOLECULAR CHEMISTRY; v. 10, n. 38, p. 7681-7684, 2012.
Web of Science Citations: 32
Abstract

An eco-friendly synthesis of highly functionalized epoxides and their incorporation into an organocatalytic multicomponent approach are reported. For this, a modified class of diarylprolinol silyl ethers was designed to enable high catalytic activity in an environmentally benign solvent system. The one-pot procedure showed great efficiency in promoting stereoselective multicomponent transformations in a tandem, `green' fashion. Because of its non-residual, efficient and selective character, this synthetic design shows promise for large-scale applications in both diversity and target-oriented syntheses. (AU)

FAPESP's process: 09/07281-0 - Asymmetric organocatalysis: design of new organocatalysts and development of new methodologies
Grantee:Márcio Weber Paixão
Support type: Research Grants - Young Investigators Grants