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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Dual Effects of Hyperprolactinemia on Carrageenan-Induced Inflammatory Paw Edema in Rats

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Ochoa-Amaya, Julieta E. [1] ; Malucelli, Benjamin E. [2] ; Cruz-Casallas, Pablo E. [3] ; Nasello, Antonia G. [4] ; Felicio, Luciano F. [2] ; Carvalho-Freitas, Maria I. R. [2]
Total Authors: 6
[1] Univ Llanos, Fac Ciencias Agropecuarias & Recursos Nat, Escuela Med Vet & Zootecnia, Villavicencio - Colombia
[2] Univ Sao Paulo, Fac Med Vet & Zootecnia, Dept Patol, BR-05508900 Sao Paulo - Brazil
[3] Univ Llanos, Inst Acuicultura, Villavicencio - Colombia
[4] Fac Ciencias Med Santa Casa Sao Paulo, Dept Ciencias Fisiol, Sao Paulo - Brazil
Total Affiliations: 4
Document type: Journal article
Source: NEUROIMMUNOMODULATION; v. 18, n. 4, p. 245-253, 2011.
Web of Science Citations: 9

Objectives: The effects of short-term 5-day and long-term 30-day hyperprolactinemia induced by domperidone (1.7 mg/kg/day, s.c.) or ectopic pituitary graft on the acute inflammatory response induced by carrageenan were evaluated in male rats. Both models of hyperprolactinemia effectively increased serum prolactin (PRL) levels. Methods: The volume in milliliters of inflammatory edema was measured by plethysnnography 1, 2, 3, 4, 6, 8 and 24 h after carrageenan injection. The areas under the inflammatory time-response curves were compared. Additionally, the effects of hyperprolactinemia on body weight and serum corticosterone levels were evaluated. Results: In both domperidone-treated and pituitary graft-implanted animals, short-term 5-day hyperprolactinemia increased the inflammatory response, while long-term 30-day hyperprolactinemia had anti-inflammatory effects. Body weight was not affected by either short- or long-term hyperprolactinennia. Conclusion: These results show that PRL has biphasic effects on the carrageenan-induced inflammatory response. Copyright (C) 2011 S. Karger AG, Basel (AU)