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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Clinico-genetic aspects of a pediatric non-neurofibromatosis type 1 malignant triton tumor with loss of chromosome X

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Author(s):
Engel, Edgard Eduard [1] ; Brassesco, Maria Sol [2] ; Valera, Elvis Terci [2] ; Nogueira-Barbosa, Marcello Henrique [3] ; de Almeida Santos Yamashita, Mauricio Eiji [4] ; Scrideli, Carlos Alberto [2] ; Tone, Luiz Gonzaga [2]
Total Authors: 7
Affiliation:
[1] Univ Sao Paulo, Dept Orthopaed & Traumatol, Sch Med Ribeirao Preto, BR-14049 Ribeirao Preto - Brazil
[2] Univ Sao Paulo, Div Pediat Oncol, Sch Med Ribeirao Preto, Dept Pediat, BR-14049 Ribeirao Preto - Brazil
[3] Univ Sao Paulo, Div Diagnost Imaging, Sch Med Ribeirao Preto, Dept Internal Med, BR-14049 Ribeirao Preto - Brazil
[4] Univ Sao Paulo, Dept Pathol, Sch Med Ribeirao Preto, BR-14049 Ribeirao Preto - Brazil
Total Affiliations: 4
Document type: Journal article
Source: PEDIATRIC BLOOD & CANCER; v. 59, n. 7, p. 1320-1323, DEC 2012.
Web of Science Citations: 2
Abstract

Malignant triton tumor (MTT) is an aggressive peripheral nerve sheath tumor with rhabdomyoblastic differentiation. Less than 100 cases have been described, being mostly male children with type 1 neurofibromatosis. We report a 6-year-old female with MTT and no diagnostic criteria for neurofibromatosis type 1. Cytogenetic analysis showed a 46,X,-X{[}4]/46,XX{[}16] karyotype. She underwent a transfemoral amputation and chemotherapy and is free of disease 15 months after diagnosis. The few cytogenetic studies of MTT described in the literature have been inconclusive. Further cytogenetic analyses are needed to understand the role of chromosome X monosomy in the pathogenesis of this rare tumor. Pediatr Blood Cancer 2012; 59: 13201323. (C) 2012 Wiley Periodicals, Inc. (AU)

FAPESP's process: 10/15717-0 - Analysis of chromosomal aberrations in childhood cancer through conventional and molecular cytogenetics
Grantee:Elvis Terci Valera
Support type: Regular Research Grants
FAPESP's process: 10/16652-9 - NF-kB inhibition in glioblastoma: in vitro and in vivo effects of DHMEQ in tumor chemoresistance, invasion and progression
Grantee:María Sol Brassesco Annichini
Support type: Scholarships in Brazil - Young Researchers