Cafeteria diet intake for fourteen weeks can cause obesity and insulin resistance in Wistar rats

Author(s)

Correa Pinto Junior, Danilo Antonio ^[1] ; Seraphim, Patricia Monteiro ^[1]

Affiliation

^[1] Univ Estadual Paulista, Fac Ciencias & Tecnol Presidente Prudente, BR-19060900 Presidente Prudente, SP - Brazil

• Document type: Journal article
• Source: REVISTA DE NUTRICAO-BRAZILIAN JOURNAL OF NUTRITION; v. 25, n. 3, p. 313-319, MAY-JUN 2012.
• Web of Science Citations: 6

Abstract

OBJECTIVE: Obesity is a strong predictor of some kinds of diseases. High intake of high-fat foods contributes significantly to the growth of the obese population globally. The aim of this study was to verify if consumption of a cafeteria diet for fourteen weeks could increase white fat mass, body weight and skeletal muscle mass and promote insulin resistance in male Wistar rats. METHODS: Twenty animals were divided into two groups: control and obese. Both were fed standard chow and water ad libitum. Additionally, a cafeteria diet consisting of bacon, bologna sausage, sandwich cookies and soft drink was given to the obese group. RESULTS: The obese group was significantly heavier (p<0.0001) than controls from the second week until the end of the cafeteria-diet intervention. Absolute and relative fat mass, liver weight and Lee Index increased significantly (p<0.05) in the obese group. Furthermore, the obese group had lower (p<0.05) insulin sensitivity than the control group. CONCLUSION: In conclusion, fourteen weeks of cafeteria diet promoted a progressive increase of fat mass and insulin resistance. Therefore, this is a great and inexpensive diet-induced insulin resistance model. (AU)

• FAPESP's process: 09/13475-1 - EFFECTS OF COMBINED AEROBIC AND ANAEROBIC EXERCISES ON INSULIN SIGNALING AND ON GLUCOSE TRANSPORTER IN SKELETAL MUSCLES
• Grantee: Danilo Antônio Corrêa Pinto Júnior
• Support Opportunities: Scholarships in Brazil - Master