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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Role of TLR-2 and Fungal Surface Antigens on Innate Immune Response Against Sporothrix schenckii

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Author(s):
Negrini, Thais de C. [1] ; Ferreira, Lucas S. [1] ; Alegranci, Pamela [1] ; Arthur, Rodrigo A. [2, 3] ; Sundfeld, Pedro P. [1] ; Maia, Danielle C. G. [1] ; Spolidorio, Luis C. [4] ; Carlos, Iracilda Z. [1]
Total Authors: 8
Affiliation:
[1] Sao Paulo State Univ, Araraquara Sch Pharmaceut Sci, Dept Clin Anal, BR-14801902 Araraquara, SP - Brazil
[2] Univ Fed Rio Grande do Sul, Sch Dent, Dept Prevent & Community Dent, BR-90046900 Porto Alegre, RS - Brazil
[3] Indiana Univ, Sch Dent, Dept Prevent & Community Dent, Indianapolis, IN - USA
[4] Sao Paulo State Univ, Araraquara Sch Dent, Dept Physiol & Pathol, BR-14801902 Araraquara, SP - Brazil
Total Affiliations: 4
Document type: Journal article
Source: IMMUNOLOGICAL INVESTIGATIONS; v. 42, n. 1, p. 36-48, 2013.
Web of Science Citations: 27
Abstract

Sporotrichosis is an infection caused by the dimorphic fungus Sporothrix schenckii. Toll-like receptors (TLRs) play an important role in immunity, since they bind to pathogen surface antigens and initiate the immune response. However, little is known about the role of TLR-2 and fungal surface antigens in the recognition of S. schenckii and in the subsequent immune response. This study aimed to evaluate the involvement of TLR-2 and fungal surface soluble (SolAg) and lipidic (LipAg) antigens in phagocytosis of S. schenckii and production of immune mediators by macrophages obtained from WT and TLR-2(-/-) animals. The results showed that TLR-2(-/-) animals had had statistical lower percentage of macrophages with internalized yeasts compared to WT. SolAg and LipAg impaired phagocytosis and immunological mediator production for both WT and TLR-2(-/-). The absence of TLR-2 led to lower production of the cytokines TNF-alpha, IL-1 beta, IL-12 and IL-10 compared to WT animals. These results suggest a new insight in relation to how the immune system, through TLR-2, recognizes and induces the production of mediators in response to the fungus S. schenckii. (AU)

FAPESP's process: 09/11999-3 - Influence of TLR-2 and TLR-4 receptors in host defense against the fungus Sporothrix schenckii
Grantee:Iracilda Zeppone Carlos
Support Opportunities: Regular Research Grants
FAPESP's process: 09/07529-1 - Influence of TLR-2 receptors in host defense against the fungus Sporothrix schenckii
Grantee:Thais de Cassia Negrini
Support Opportunities: Scholarships in Brazil - Doctorate