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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Cyclosporin A causes impairment of the ventral prostate tissue structure of Wistar rats

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Author(s):
Freitas, K. M. [1] ; Monteiro, J. C. [2] ; Gomes, M. L. M. [3] ; Taboga, S. R. [4] ; Dolder, H. [1]
Total Authors: 5
Affiliation:
[1] Univ Campinas IB UNICAMP, Inst Biol, Dept Struct & Funct Biol, Campinas, SP - Brazil
[2] Univ Fed Espirito Santo, Dept Agron & Biol Sci, CEUNES, Sao Mateus - Brazil
[3] Univ Fed Espirito Santo, Dept Hlth Sci, CEUNES, Sao Mateus - Brazil
[4] Univ Sao Paulo, IBILCE State, Dept Biol, Sao Jose Do Rio Preto - Brazil
Total Affiliations: 4
Document type: Journal article
Source: HUMAN & EXPERIMENTAL TOXICOLOGY; v. 31, n. 12, p. 1262-1270, DEC 2012.
Web of Science Citations: 5
Abstract

Cyclosporin A (CsA) is an immunosuppressive drug widely used in medicine to reduce the immune system activity and, therefore, the risk of organ rejection after transplantation. However, many side effects can be related to its use, such as, reduction in serum testosterone levels due to damage of the testis structure and, consequently, male infertility. The present study aims to evaluate the effects of chronic CsA administration on the ventral prostate tissue ( 1 5 mg/kg per d, for 56 days). Stereological, morphometrical, morphological and ultrastructural observations were employed. The plasmatic testosterone and glucose levels were measured. An androgen receptor (AR) immunohistochemical method was applied on ventral prostate sections. Apoptosis was detected with the terminal deoxynucleotidyl transferase dUTP nick end labeling technique. CsA treatment caused reduction in plasmatic testosterone levels and an increase in glycemia. The volume of all ventral prostate tissue components (lumen, epithelium and muscular and nonmuscular stroma) and ventral prostate weight were reduced in the CsA-treated group. Light and transmission electron microscopy confirmed epithelium atrophy of treated animals. There was no alteration of AR expression or apoptotic index. CsA chronic treatment in the therapeutic doses caused damage to prostate tissue of adult Wistar rats, probably due to increase in the glucose levels and reduction in the plasmatic testosterone levels. (AU)

FAPESP's process: 09/07824-3 - Effect of cyclosporine A associated with "nó-de-cachorro" infusion (Heteropterys aphrodisiaca, O. Mach, 1949) on the prostate of Wistar rats
Grantee:Karine Moura de Freitas
Support Opportunities: Scholarships in Brazil - Master