Performance of surveillance cultures at different body sites to identify asymptomatic Staphylococcus aureus carriers

Author(s):Show less -

Cursino, Maria A. ^{[1, 2]} ; Garcia, Cilmara P. ^{[1, 2, 3]} ; Lobo, Renata D. ^[3] ; Salomao, Matias C. ^{[1, 2]} ; Gobara, Satiko ^[3] ; Raymundo, Gabriela F. ^{[1, 2]} ; Kespers, Thaisa ^{[1, 2]} ; Soares, Robson E. ^{[1, 2]} ; Mollaco, Carla H. ^[3] ; Keil, Kleiste G. ^[3] ; Malieno, Paula B. ^[3] ; Krebs, Vera L. ^[4] ; Gibelli, Maria Augusta ^[4] ; Kondo, Mario M. ^[5] ; Zugaib, Marcelo ^[5] ; Costa, Silvia F. ^{[1, 2]} ; Levin, Anna S. ^{[1, 2, 3]}

Affiliation

^[1] Univ Sao Paulo, Dept Infect Dis, BR-05403900 Sao Paulo - Brazil

^[2] Univ Sao Paulo, LIM 54, BR-05403900 Sao Paulo - Brazil

^[3] Univ Sao Paulo, Dept Infect Control, Hosp Clin, BR-05403010 Sao Paulo - Brazil

^[4] Univ Sao Paulo, Dept Pediat, BR-05403901 Sao Paulo - Brazil

^[5] Univ Sao Paulo, Dept Obstet, BR-05403900 Sao Paulo - Brazil

• Document type: Journal article
• Source: DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE; v. 74, n. 4, p. 343-348, DEC 2012.
• Web of Science Citations: 11

Abstract

The objective was to evaluate the performance of surveillance cultures at various body sites for Staphylococcus aureus colonization in pregnant women and newborns (NB) and the factors associated with nasal colonization. For NB, 4 sites were evaluated: nares, oropharynx, perineum, and umbilical stump (birth, third day, and weekly). For pregnant women, 4 sites during labor: anterior nares, anus, perineum, and oropharynx. Nasally colonized patients were compared with colonized only extranasally. Colonization was 53% of 392 pregnant women (methicillin-resistant S. aureus {[}MRSA]: 4%) and 47% of 382 NB (MRSA: 9%). For newborn patients, the best body site was the umbilical stump (methicillin-susceptible S. aureus {[}MSSA]: 64%; MRSA: 68%) and the combination of nares + umbilical (MSSA: 86%; MRSA: 91%). Among pregnant women, the best body site was the anterior nares (MSSA: 59%; MRSA: 67%) and the combination of nares + oropharynx (MSSA: 83%; MRSA: 80%). A smaller number of household members were associated with MRSA carriage in pregnant women (2.2 +/- 0.6 versus 3.6 +/- 1.8; P = 0.04). In conclusion, multiple culture sites are needed. Control programs based on surveillance cultures may be compromised. (C) 2012 Elsevier Inc. All rights reserved. (AU)

• FAPESP's process: 09/08206-1 - Factors associated with acquiring methicillin-resistant Staphylococcus aureus in newborns
• Grantee: Anna Sara Shafferman Levin
• Support Opportunities: Regular Research Grants