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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Purinergic transmission in the rostral but not caudal medullary raphe contributes to the hypercapnia-induced ventilatory response in unanesthetized rats

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Author(s):
da Silva, Glauber S. F. [1] ; Moraes, Davi J. A. [1] ; Giusti, Humberto [1] ; Dias, Mirela Barros [2] ; Glass, Mogens L. [1]
Total Authors: 5
Affiliation:
[1] Univ Sao Paulo, FMRP, Dept Physiol, BR-14049900 Ribeirao Preto, SP - Brazil
[2] Univ Fed Goias, Dept Physiol Sci, Goiania, Go - Brazil
Total Affiliations: 2
Document type: Journal article
Source: Respiratory Physiology & Neurobiology; v. 184, n. 1, p. 41-47, OCT 15 2012.
Web of Science Citations: 6
Abstract

The medullary raphe (MR) is a putative central chemoreceptor site, contributing to hypercapnic respiratory responses elicited by changes in brain PCO2/pH. Purinergic mechanisms in the central nervous system appear to contribute to central chemosensitivity. To further explore the role of P2 receptors within the rostral and caudal MR in relation to respiratory control in room air and hypercapnic conditions, we performed microinjections of PPADS, a non-selective P2X antagonist, in conscious rats. Microinjections of PPADS into the rostral or caudal MR produced no changes in the respiratory frequency, tidal volume and ventilation in room air condition. The ventilatory response to hypercapnia was attenuated after microinjection of PPADS into the rostral but not in the caudal MR when compared to the control group (vehicle microinjection). These data suggest that P2X receptors in the rostral MR contribute to the ventilatory response to CO2, but do not participate in the tonic maintenance of ventilation under room air condition in conscious rats. (C) 2012 Elsevier B.V. All rights reserved. (AU)