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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Molecular Adaptations to Concurrent Training

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Author(s):
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de Souza, E. O. [1] ; Tricoli, V. [1] ; Roschel, H. [1] ; Brum, P. C. [1] ; Bacurau, A. V. N. [1] ; Ferreira, J. C. B. [1, 2] ; Aoki, M. S. [3] ; Neves-, Jr., M. [4] ; Aihara, A. Y. [5] ; Correa Fernandes, A. da Rocha [6] ; Ugrinowitsch, C. [1]
Total Authors: 11
Affiliation:
[1] Univ Sao Paulo, Sch Phys Educ & Sport, Dept Sport, BR-05508030 Sao Paulo - Brazil
[2] Stanford Univ, Sch Med, Stanford, CA 94305 - USA
[3] Univ Sao Paulo, Sch Arts, Sao Paulo - Brazil
[4] Univ Sao Paulo, Sch Med, Sao Paulo - Brazil
[5] DASA, , Sao Paulo - Brazil
[6] Univ Fed Sao Paulo, Dept Radiol, Sao Paulo - Brazil
Total Affiliations: 6
Document type: Journal article
Source: INTERNATIONAL JOURNAL OF SPORTS MEDICINE; v. 34, n. 3, p. 207-213, MAR 2013.
Web of Science Citations: 18
Abstract

This study investigated the chronic effects of concurrent training (CT) on morphological and molecular adaptations. 37 men (age = 23.7 +/- 5.5 year) were divided into 4 groups: interval (IT), strength (ST) and concurrent (CT) training and a control group (C) and underwent 8 weeks of training. Maximum strength (1RM) and muscle cross-sectional area (CSA) were evaluated before and after training. Muscle samples were obtained before the training program and 48 h after the last training session. VO2max improved in 5 +/- 0.95 % and 15 +/- 1.3 % (pre- to post-test) in groups CT and IT, respectively, when compared to C. Time to exhaustion (TE) improved from pre- to post-test when compared to C (CT = 6.1 +/- 0.58 %; IT = 8.3 +/- 0.88 %; ST = 3.2 +/- 0.66 %). 1RM increased from pre-to post-test only in ST and CT groups (ST = 18.5 +/- 3.16 %; CT = 17.6 +/- 3.01 %). Similarly, ST and CT groups increased quadriceps CSA from pre-to post-test (6.2 +/- 1.4 %; 7.8 +/- 1.66 %). The p70S6K1 total protein content increased after CT. The ST group showed increased Akt phosphorylation at Ser473 (45.0 +/- 3.3 %) whereas AMPK phosphorylation at Thr172 increased only in IT group, (100 +/- 17.6 %). In summary, our data suggest that despite the differences in molecular adaptations between training regimens, CT did not blunt muscle strength and hypertrophy increments when compared with ST. (AU)

FAPESP's process: 09/03143-1 - Protein quality control in heart failure: role of different protein kinase C isozymes
Grantee:Julio Cesar Batista Ferreira
Support type: Scholarships in Brazil - Post-Doctorate