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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Outbreak of carbapenem-resistant Klebsiella pneumoniae: two-year epidemiologic follow-up in a tertiary hospital

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Author(s):
Pereira, Graziella Hanna [1] ; Garcia, Doroti O. [2] ; Mostardeiro, Marcelo [1] ; Fanti, Karina S. V. N. [1] ; Levin, Anna S. [3]
Total Authors: 5
Affiliation:
[1] Hosp Brigadeiro, Dept Controle Infeccao, Sao Paulo, SP - Brazil
[2] Adolfo Lutz Inst, Ctr Bacteriol, Sao Paulo - Brazil
[3] Univ Sao Paulo, Fac Med, Hosp Clin, Lab Invest Med, Dept Doencas Infecciosas & Parasit, Sao Paulo - Brazil
Total Affiliations: 3
Document type: Journal article
Source: Memórias do Instituto Oswaldo Cruz; v. 108, n. 1, p. 113-115, FEB 2013.
Web of Science Citations: 7
Abstract

This study describes a carbapenem-resistant Klebsiella pneumoniae (CRKP) outbreak that occurred from October 2008-December 2010. Polymerase chain reaction assays were performed to detect the blaKPC gene and molecular typing was performed using pulsed-field gel electrophoresis (PFGE). There were 33 CRKP infections; PFGE revealed five genotypes: genotype A in five (15%), B in 18 (55%), C in eight (24%) and two unique profiles. Genotype B was disseminated in all hospital units and belonged to the same clone identified in 11 different hospitals in the state of São Paulo. Sixteen (48%) patients died. Seven isolates (21%) were resistant to polymyxin B and 45% were resistant to tigecycline and amikacin. (AU)

FAPESP's process: 09/53229-0 - Detection of antimicrobial resistance genes in Klebsiella pneumoniae isolated from nosocomial infection or colonization from several hospitals of São Paulo State, Brazil
Grantee:Doroti de Oliveira Garcia
Support Opportunities: Research Grants - Research in Public Policies for the National Health Care System (PP-SUS)