Advanced search
Start date
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Ethanol-Induced Memory Impairment in a Discriminative Avoidance Task is State-Dependent

Full text
Sanday, Leandro [1] ; Patti, Camilla L. [1, 2] ; Zanin, Karina A. [2, 1] ; Fernandes-Santos, Luciano [1, 2] ; Oliveira, Larissa C. [1] ; Kameda, Sonia R. [2, 1] ; Tufik, Sergio [2] ; Frussa-Filho, Roberto [1, 2]
Total Authors: 8
[1] Univ Fed Sao Paulo, Dept Farmacol, Sao Paulo - Brazil
[2] Univ Fed Sao Paulo, Dept Psicobiol, Sao Paulo - Brazil
Total Affiliations: 2
Document type: Journal article
Web of Science Citations: 11

Background A considerable amount of experimental evidence has demonstrated ethanol (EtOH) induced amnestic effects following EtOH administration during pretraining in a variety of tasks both in humans and in laboratory animals. Although the phenomenon of state-dependency is known to play a critical role in memory deficits induced by both pharmacological and nonpharmacological pretraining perturbations, the involvement of this phenomenon in EtOH-induced anterograde amnesia has been overlooked. This study aimed to investigate the role of state-dependency in EtOH-induced amnestic effects and its interactions with the well-known anxiolysis and locomotor alterations. Methods Mice were treated with 1.2 or 2.4 g/kg EtOH before training and/or before testing in the plus-maze discriminative avoidance task, an animal model that concomitantly evaluates learning, memory, anxiety-like behavior, and general activity. Results Whereas both doses of EtOH induced anxiolysis, the 1.2 g/kg dose enhanced locomotion while the 2.4 g/kg dose decreased it. In addition, the administration of 1.2 g/kg of this drug during pretraining caused memory impairment, which was counteracted by the pretest administration of the same dose, revealing the participation of the state-dependency. Conversely, the administration of 2.4 g/kg EtOH led to amnestic effects irrespective of the time of the administration (pretraining and/or pretest), eliminating the influence of state-dependency. Conclusions Our data demonstrate that EtOH-induced memory deficits are critically related to state-dependency, which can also be affected by the dose range. These results indicate the possible participation of EtOH-induced modifications in anxiety and motor activity levels in relation to state-dependent memory deficits. (AU)

FAPESP's process: 98/14303-3 - Center for Sleep Studies
Grantee:Sergio Tufik
Support type: Research Grants - Research, Innovation and Dissemination Centers - RIDC
FAPESP's process: 08/08823-8 - Effects of zolpidem on learning and memory of mice submitted to plus-maze discriminative avoidance task
Grantee:Karina Agustini Zanin
Support type: Scholarships in Brazil - Master