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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Lack of evidence to support the association of a single IL28B genotype SNP rs12979860 with the HTLV-1 clinical outcomes and proviral load

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Sanabani, Sabri Saeed [1, 2] ; Nukui, Youko [3] ; Pereira, Juliana [3] ; da Costa, Antonio Charlys [1] ; Soares de Oliveira, Ana Carolina [1] ; Pessoa, Rodrigo [1] ; Leal, Fabio Eudes [4] ; Segurado, Aluisio C. [5] ; Kallas, Esper Georges [4] ; Sabino, Ester Cerdeira [5]
Total Authors: 10
[1] Univ Sao Paulo, Clin Lab, Dept Pathol, LIM 03, HC, Sch Med, Sao Paulo - Brazil
[2] Sao Paulo Inst Trop Med, Sao Paulo - Brazil
[3] Univ Sao Paulo, Dept Hematol, Sao Paulo - Brazil
[4] Univ Sao Paulo, Div Clin Immunol & Allergy, Sch Med, Sao Paulo - Brazil
[5] Univ Sao Paulo, Dept Infect Dis, Sch Med, Sao Paulo - Brazil
Total Affiliations: 5
Document type: Journal article
Source: BMC INFECTIOUS DISEASES; v. 12, DEC 23 2012.
Web of Science Citations: 9

Background: The Interleukin 28B (IL28B) rs12979860 polymorphisms was recently reported to be associated with the human T-cell leukemia virus type 1 (HTLV-1) proviral load (PvL) and the development of the HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Methods: In an attempt to examine this hypothesis, we assessed the association of the rs12979860 genotypes with HTLV-1 PvL levels and clinical status in 112 unrelated Brazilian subjects (81 HTLV-1 asymptomatic carriers, 24 individuals with HAM/TSP and 7 with Adult T cell Leukemia/Lymphoma (ATLL)). Results: All 112 samples were successfully genotyped and their PvLs compared. Neither the homozygote TT nor the heterozygote CT mutations nor the combination genotypes (TT/CT) were associated with a greater PvL. We also observed no significant difference in allele distribution between asymptomatic carriers and patients with HTLV-1 associated HAM/TSP. Conclusions: Our study failed to support the previously reported positive association between the IL28B rs12979860 polymorphisms and an increased risk of developing HAM/TSP in the Brazilian population. (AU)

FAPESP's process: 10/08550-1 - T cell clonal expansion and proviral load levels among human t cell lymphotropic virus type 1 (HTLV-1) asymptomatic carriers
Grantee:Ester Cerdeira Sabino
Support type: Regular Research Grants
FAPESP's process: 11/12297-2 - Profiling the human T-cells miRNA, REX and tax transcriptomes in the course of HTLV-1 infection using a deep sequencing approach
Grantee:Sabri Saeed Mohamed Ahmed Al-Sanabani
Support type: Regular Research Grants